{"id":36438065,"url":"https://github.com/InsightRX/PKPDsim","last_synced_at":"2026-01-27T00:00:53.601Z","repository":{"id":24068789,"uuid":"100528653","full_name":"InsightRX/PKPDsim","owner":"InsightRX","description":"Simulate PK-PD models defined as ODE systems","archived":false,"fork":false,"pushed_at":"2026-01-16T20:19:53.000Z","size":46010,"stargazers_count":44,"open_issues_count":5,"forks_count":15,"subscribers_count":10,"default_branch":"master","last_synced_at":"2026-01-17T05:39:47.733Z","etag":null,"topics":["ode","pharmacodynamics","pharmacokinetics","pharmacometrics","r"],"latest_commit_sha":null,"homepage":"https://insightrx.github.io/PKPDsim/","language":"R","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":"other","status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/InsightRX.png","metadata":{"files":{"readme":"README.md","changelog":"NEWS.md","contributing":null,"funding":null,"license":"LICENSE","code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null,"roadmap":null,"authors":null,"dei":null,"publiccode":null,"codemeta":null,"zenodo":null,"notice":null,"maintainers":null,"copyright":null,"agents":null,"dco":null,"cla":null}},"created_at":"2017-08-16T20:11:43.000Z","updated_at":"2025-11-24T23:15:16.000Z","dependencies_parsed_at":"2023-02-16T21:31:29.921Z","dependency_job_id":"76cb3766-ddca-4b05-94ce-0d6d170501cf","html_url":"https://github.com/InsightRX/PKPDsim","commit_stats":{"total_commits":901,"total_committers":12,"mean_commits":75.08333333333333,"dds":0.5538290788013318,"last_synced_commit":"2f14e1cb3927e0d2813459551d821fe162f61be5"},"previous_names":[],"tags_count":50,"template":false,"template_full_name":null,"purl":"pkg:github/InsightRX/PKPDsim","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/InsightRX%2FPKPDsim","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/InsightRX%2FPKPDsim/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/InsightRX%2FPKPDsim/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/InsightRX%2FPKPDsim/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/InsightRX","download_url":"https://codeload.github.com/InsightRX/PKPDsim/tar.gz/refs/heads/master","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/InsightRX%2FPKPDsim/sbom","scorecard":null,"host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":286080680,"owners_count":28791346,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2026-01-26T21:49:50.245Z","status":"ssl_error","status_checked_at":"2026-01-26T21:48:29.455Z","response_time":59,"last_error":"SSL_read: unexpected eof while reading","robots_txt_status":"success","robots_txt_updated_at":"2025-07-24T06:49:26.215Z","robots_txt_url":"https://github.com/robots.txt","online":false,"can_crawl_api":true,"host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["ode","pharmacodynamics","pharmacokinetics","pharmacometrics","r"],"created_at":"2026-01-11T20:00:23.612Z","updated_at":"2026-01-27T00:00:53.586Z","avatar_url":"https://github.com/InsightRX.png","language":"R","readme":"# PKPDsim \u003cimg src=\"man/figures/hexsticker.png\" align=\"right\" width = \"200\"/\u003e\n\n\u003c!-- badges: start --\u003e\n[![R-CMD-check](https://github.com/InsightRX/PKPDsim/actions/workflows/R-CMD-check.yaml/badge.svg)](https://github.com/InsightRX/PKPDsim/actions/workflows/R-CMD-check.yaml)\n[![CRAN status](https://www.r-pkg.org/badges/version/PKPDsim)](https://CRAN.R-project.org/package=PKPDsim)\n[![R-universe status](https://insightrx.r-universe.dev/badges/PKPDsim)](https://insightrx.r-universe.dev/PKPDsim)\n\u003c!-- badges: end --\u003e\n\nPKPDsim is a library for numerical integration of ODE systems, in particular pharmacokinetic-pharmacodynamic (PK-PD) mixed-effects models.\n\n## Installation\n\nThe development version of PKPDsim always has the most up-to-date improvements\nand bug fixes. We aim to release PKPDsim on CRAN at least once a year,\ndepending on the number and impact of updates made to the development version.\n\nThe [CRAN](https://cran.r-project.org/package=PKPDsim) version of PKPDsim can be installed using:\n\n```r\ninstall.packages(\"PKPDsim\")\n```\n\nThe development version of PKPDsim can be installed from [GitHub](https://github.com/InsightRX/PKPDsim) or [R-universe](https://insightrx.r-universe.dev/PKPDsim) using:\n\n```r\n# Install from GitHub:\ndevtools::install_github(\"InsightRX/PKPDsim\")\n\n# Install from R-universe:\ninstall.packages(\"PKPDsim\", repos = \"https://insightrx.r-universe.dev\")\n```\n\nA number of models from the literature have been made available for use in\nPKPD simulations. To see which models are available for installation, run:\n\n```r\navailable_default_literature_models()\n```\n\nYou can install these models as packages using the following commands:\n\n```r\n# To install a single model:\ninstall_default_literature_model(\"pk_busulfan_mccune\")\n\n# To install all supplied models:\ninstall_default_literature_model(\"all\")\n```\n\n## Contributing\n\nWe welcome input from the community:\n\n- If you think you have encountered a bug, please [submit an issue](https://github.com/InsightRX/PKPDsim/issues) \non the GitHub page. Please include a reproducible example of the unexpected \nbehavior.\n\n- Please [open a pull request](https://github.com/InsightRX/PKPDsim/pulls) if\nyou have a fix or updates that would improve the package. If you're not sure if\nyour proposed changes are useful or within scope of the package, feel free to\ncontact one of the authors of this package.\n\n## Disclaimer\n\nThe functionality in this R package is provided \"as is\". While its authors \nadhere to software development best practices, the software may still contain \nunintended errors.\n\nInsightRX Inc. and the authors of this package can not be held liable for any\ndamages resulting from any use of this software. By the use of this software \npackage, the user waives all warranties, expressed or implied, including any \nwarranties to the accuracy, quality or suitability of InsightRX for any \nparticular purpose, either medical or non-medical.\n\n\n\u003cdiv align=\"right\"\u003e\n© \u003cimg src=\"man/figures/insightrx_logo_color.png\" alt=\"InsightRX logo\" width=\"120\" /\u003e\n\u003c/div\u003e\n","funding_links":[],"categories":["Pharmacometrics \u0026 PK-PD"],"sub_categories":["Commercial Software"],"project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2FInsightRX%2FPKPDsim","html_url":"https://awesome.ecosyste.ms/projects/github.com%2FInsightRX%2FPKPDsim","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2FInsightRX%2FPKPDsim/lists"}