{"id":22632180,"url":"https://github.com/alleninstitute/mies","last_synced_at":"2026-01-07T08:04:01.797Z","repository":{"id":33046261,"uuid":"133561327","full_name":"AllenInstitute/MIES","owner":"AllenInstitute","description":"Multichannel Igor Electrophysiology Suite","archived":false,"fork":false,"pushed_at":"2024-06-11T16:37:55.000Z","size":446560,"stargazers_count":20,"open_issues_count":275,"forks_count":6,"subscribers_count":9,"default_branch":"main","last_synced_at":"2024-06-11T17:01:49.307Z","etag":null,"topics":["electrophysiology","igor-pro","supported"],"latest_commit_sha":null,"homepage":"https://alleninstitute.github.io/MIES/user.html","language":"IGOR 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Pro","funding_links":[],"categories":[],"sub_categories":[],"readme":"[![GitHub release (latest by date)](https://img.shields.io/github/v/release/AllenInstitute/MIES?style=plastic)](https://github.com/AllenInstitute/MIES/releases)\n[![Build Main](https://github.com/AllenInstitute/MIES/actions/workflows/build-release.yml/badge.svg?branch=main)](https://github.com/AllenInstitute/MIES/actions/workflows/build-release.yml)\n[![Documentation](https://img.shields.io/badge/docs-doxygen%2Fbreathe%2Fsphinx-blue.svg?style=plastic)](https://alleninstitute.github.io/MIES/user.html)\n[![Signed Installer](https://img.shields.io/badge/Signed%20Installer-Yes-success?style=plastic)](https://alleninstitute.github.io/MIES/developers.html#signed-installer)\n[![Coverage](https://byte-physics.de/public-downloads/aistorage/transfer/report/coverage/badge_combined.svg)](https://byte-physics.de/public-downloads/aistorage/transfer/report/coverage/)\n[![pre-commit](https://img.shields.io/badge/pre--commit-enabled-brightgreen?logo=pre-commit)](https://github.com/pre-commit/pre-commit)\n[![GitHub contributors](https://img.shields.io/github/contributors/AllenInstitute/MIES?style=plastic)](https://github.com/AllenInstitute/MIES/graphs/contributors)\n\n## Multichannel Igor Electrophysiology Suite\n\nThe Multichannel Igor Electrophysiology Suite (MIES) is a proven sweep based data acquisition\nsoftware package for [intracellular electrophysiology](https://en.wikipedia.org/wiki/Electrophysiology#Intracellular_recording) (patch clamp) \\[[1](https://www.science.org/stoken/author-tokens/ST-374/full),\n[2](https://doi.org/10.1038/s41586-021-03813-8),\n[3](https://doi.org/10.1038/s41593-019-0417-0),\n[4](https://elifesciences.org/articles/37349),\n[5](https://doi.org/10.1038/s41586-021-03813-8),\n[6](https://doi.org/10.7554/eLife.65482)\\].\nIt offers top of its class flexibility and robustness for stimulus generation, data\nacquisition, and analysis.\n\n## Highlights\n\n- Run up to five DACs in parallel for scalable data acquisition.\n- Acquire data on up to eight headstage on a single DAC to probe up to 56 connections at once.\n- Create arbitrarily complex stimulus sets with an intuitive GUI.\n- Export all data, including all of its metadata, into the industry-standard [NWBv2-format](https://doi.org/10.1101/523035) and read it back in\n- Run custom code during data acquisition for Automatic Experiment Control and real-time adaptability.\n- Automate experimental setup using configuration files for streamlined workflows.\n- Interact with MIES from other programming languages (Python, C++, Javascript, ...) through [ZeroMQ](https://zeromq.org/).\n- Track and manage your experiments with comprehensive metadata acquisition and browsing tools.\n- Leverage the integrated scripting language for flexible, on-the-fly electrophysiology data evaluation.\n- Ensure compatibility with every earlier version of MIES, protecting your previous work and workflows.\n\n## Getting started\n\n- Download the [latest release](https://github.com/AllenInstitute/MIES/releases/tag/latest)\n- Windows: Run the installer\n- MacOSX (analysis only): [Manual installation](https://alleninstitute.github.io/MIES/installation.html#manual-installation)\n- View the [documentation](https://alleninstitute.github.io/MIES/user.html)\n\n### Brief visual overview\n\n![Slideshow showing the main graphical user interfaces of MIES in Igor Pro](Packages/Artwork/readme-teaser.gif)\n\n### Postsynaptic data analysis\n\n[![Demonstration of postsynaptic data analysis](https://img.youtube.com/vi/O2WxPzBsEfc/0.jpg)](https://www.youtube.com/watch?v=O2WxPzBsEfc)\n\nVideo tutorial of the postsynaptic potential/postsynaptic current data (PSX) analysis module\n\n## Required Software\n\n- [Igor Pro 9 (nightly) or later](https://alleninstitute.github.io/MIES/installation.html#igor-pro-update-nightly)\n\n### For Data Analysis\n\n- Windows 11 64-bit or MacOSX 10.10\n\n### For Data Acquisition\n\n- Windows 11 64-bit\n- [NIDAQ MX XOP](https://www.wavemetrics.com/products/nidaqtools/nidaqtools.htm)\n\n## Supported Hardware\n\n- Digital to analog converters (DAC):\n  - National Instruments:\n    - [PCIe-6341](https://www.ni.com/de-de/support/model.pcie-6341.html)\n    - [PCIe-6343](https://www.ni.com/en-us/support/model.pcie-6343.html)\n    - [PXI-6259](https://www.ni.com/en-us/support/model.pxi-6259.html)\n    - [USB-6346](https://www.ni.com/de-de/support/model.usb-6346.html)\n\n      Other NI hardware models can be added on request. Please open an issue from within MIES,\n  `MIES Panels-\u003eReport an issue`, for that.\n\n  Better results are obtained if your hardware's analog input channels support Referenced Single Ended (RSE)\n  Terminal Configuration, but Differential is also supported as a fallback. See also\n  [this](https://knowledge.ni.com/KnowledgeArticleDetails?id=kA00Z0000019QRZSA2) article from NI Support.\n\n  - Instrutech/HEKA ITC:\n    - [16](http://www.heka.com/downloads/hardware/manual/itc16.pdf)\n    - [18](http://www.heka.com/downloads/hardware/manual/m_itc18.pdf)\n    - [1600](http://www.heka.com/downloads/hardware/manual/m_itc1600.pdf)\n\n     ITC devices are at the End-Of-Service-Life (EOSL). National Instruments DACs are recommended for MIES users looking for new hardware.\n\n- Amplifier: Molecular Devices [700B](https://www.moleculardevices.com/products/axon-patch-clamp-system/amplifiers/axon-instruments-patch-clamp-amplifiers)\n- Pressure control (optional):\n  - [QPV High Resolution Pressure Regulator](https://proportionair.com/product/qpv/) from Proportion-Air, Inc.; Part name: QPV regulator (custom, see part No), -10 psi to +10 psi; Part no.: QPV1TBNEEN10P10PSGAXLDD\n  - controlled through ITC 18/1600 or National Instruments [USB 6001](https://www.ni.com/en-us/support/model.usb-6001.html)\n\n## Support statement\n\nThe last released version receives fixes for all critical bugs.\n\n## Bug reporting\n\n[Report a Bug](https://alleninstitute.github.io/MIES/reportingbugs.html)\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Falleninstitute%2Fmies","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Falleninstitute%2Fmies","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Falleninstitute%2Fmies/lists"}