{"id":21022564,"url":"https://github.com/alro10/nonlinear-fitting-kinetics-dnaandrnap","last_synced_at":"2026-03-17T17:08:25.871Z","repository":{"id":121033080,"uuid":"181357784","full_name":"Alro10/nonlinear-fitting-kinetics-DNAandRNAP","owner":"Alro10","description":"Nonlinear regression using to estimate kinetics constants of DNA promoter opening and escape during transcription initiation complex assembled between Lambda PR promoter and E. coli RNA polymerase.","archived":false,"fork":false,"pushed_at":"2019-04-16T01:55:49.000Z","size":54,"stargazers_count":1,"open_issues_count":0,"forks_count":0,"subscribers_count":0,"default_branch":"master","last_synced_at":"2025-12-28T04:29:31.916Z","etag":null,"topics":["exponential","fitting","nonlinear-regression","rna","rna-polymerase"],"latest_commit_sha":null,"homepage":null,"language":null,"has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":"mit","status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/Alro10.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":"LICENSE","code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null,"roadmap":null,"authors":null,"dei":null,"publiccode":null,"codemeta":null}},"created_at":"2019-04-14T19:20:29.000Z","updated_at":"2019-04-16T01:55:50.000Z","dependencies_parsed_at":null,"dependency_job_id":"f33086b3-cf3f-4356-a6df-a8b09a55ddff","html_url":"https://github.com/Alro10/nonlinear-fitting-kinetics-DNAandRNAP","commit_stats":null,"previous_names":[],"tags_count":0,"template":false,"template_full_name":null,"purl":"pkg:github/Alro10/nonlinear-fitting-kinetics-DNAandRNAP","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Alro10%2Fnonlinear-fitting-kinetics-DNAandRNAP","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Alro10%2Fnonlinear-fitting-kinetics-DNAandRNAP/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Alro10%2Fnonlinear-fitting-kinetics-DNAandRNAP/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Alro10%2Fnonlinear-fitting-kinetics-DNAandRNAP/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/Alro10","download_url":"https://codeload.github.com/Alro10/nonlinear-fitting-kinetics-DNAandRNAP/tar.gz/refs/heads/master","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Alro10%2Fnonlinear-fitting-kinetics-DNAandRNAP/sbom","scorecard":null,"host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":286080680,"owners_count":30627763,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2026-03-17T14:16:03.965Z","status":"ssl_error","status_checked_at":"2026-03-17T14:16:03.380Z","response_time":56,"last_error":"SSL_read: unexpected eof while reading","robots_txt_status":"success","robots_txt_updated_at":"2025-07-24T06:49:26.215Z","robots_txt_url":"https://github.com/robots.txt","online":false,"can_crawl_api":true,"host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["exponential","fitting","nonlinear-regression","rna","rna-polymerase"],"created_at":"2024-11-19T11:12:48.421Z","updated_at":"2026-03-17T17:08:25.854Z","avatar_url":"https://github.com/Alro10.png","language":null,"funding_links":[],"categories":[],"sub_categories":[],"readme":"# Nonlinear fitting kinetics DNA and RNAP\nNonlinear regression using to estimate kinetics constants of DNA promoter opening and escape during transcription initiation complex assembled between Lambda PR promoter and E. coli RNA polymerase. Based on [Kinetics of promoter escape by bacterial RNA polymerase: effects of\npromoter contacts and transcription bubble collapse](https://www.researchgate.net/publication/263709791_Kinetics_of_promoter_escape_by_bacterial_RNA_polymerase_Effects_of_promoter_contacts_and_transcription_bubble_collapse).\n\nunder developing!\n\n## Requirements\n```\nnumpy =1.16.2\nscipy = 1.2.1\nmatplotlib = 1.5.1\n```\n## Approach\n**What is a simple method to fit and estimate constants of that exponential function?**\n\n\n\u003cp align=\"center\"\u003e\n\u003cimg src=\"https://github.com/Alro10/nonlinear-fitting-kinectics-DNAandRNAP/blob/master/fitting.png\" alt=\"alt text\" width=\"80%\" height=\"80%\"\u003e\n\u003c/p\u003e\n\n## User guide \n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Falro10%2Fnonlinear-fitting-kinetics-dnaandrnap","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Falro10%2Fnonlinear-fitting-kinetics-dnaandrnap","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Falro10%2Fnonlinear-fitting-kinetics-dnaandrnap/lists"}