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However, the\nmain bottleneck of PyVCF is when you want to modify the per-sample\ngenotype information. There are some issues in the tracker of PyVCF but\nnone of them can really be considered solved. I tried several hours to\nsolve these problems within PyVCF but this never got far or towards a\ncomplete rewrite...\n\nFor this reason, VCFPy was born and here it is!\n\n## What's the State?\n\nVCFPy is the result of two full days of development plus some\nmaintenance work later now (right now). I'm using it in several projects\nbut it is not as battle-tested as PyVCF.\n\n## Why Python 3 Only?\n\nAs I'm only using Python 3 code, I see no advantage in carrying around\nsupport for legacy Python 2 and maintaining it. At a later point when\nVCFPy is known to be stable, Python 2 support might be added if someone\ncontributes a pull request.\n\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fbihealth%2Fvcfpy","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fbihealth%2Fvcfpy","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fbihealth%2Fvcfpy/lists"}