{"id":15906874,"url":"https://github.com/csinva/axon-ap-propagation","last_synced_at":"2026-02-04T01:08:07.035Z","repository":{"id":97069736,"uuid":"80491278","full_name":"csinva/axon-ap-propagation","owner":"csinva","description":"Code for simulations of action potential propagation","archived":false,"fork":false,"pushed_at":"2017-05-19T18:50:07.000Z","size":7923,"stargazers_count":1,"open_issues_count":0,"forks_count":1,"subscribers_count":3,"default_branch":"master","last_synced_at":"2025-06-04T08:18:09.577Z","etag":null,"topics":["action-potential","axon","neuron-simulations","neuroscience","simulation"],"latest_commit_sha":null,"homepage":null,"language":"AMPL","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":null,"status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/csinva.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":null,"code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null,"roadmap":null,"authors":null,"dei":null,"publiccode":null,"codemeta":null}},"created_at":"2017-01-31T04:33:12.000Z","updated_at":"2020-01-03T17:31:07.000Z","dependencies_parsed_at":"2023-06-25T23:49:35.521Z","dependency_job_id":null,"html_url":"https://github.com/csinva/axon-ap-propagation","commit_stats":null,"previous_names":[],"tags_count":0,"template":false,"template_full_name":null,"purl":"pkg:github/csinva/axon-ap-propagation","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/csinva%2Faxon-ap-propagation","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/csinva%2Faxon-ap-propagation/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/csinva%2Faxon-ap-propagation/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/csinva%2Faxon-ap-propagation/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/csinva","download_url":"https://codeload.github.com/csinva/axon-ap-propagation/tar.gz/refs/heads/master","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/csinva%2Faxon-ap-propagation/sbom","host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":263271505,"owners_count":23440396,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2022-07-04T15:15:14.044Z","host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["action-potential","axon","neuron-simulations","neuroscience","simulation"],"created_at":"2024-10-06T13:42:02.704Z","updated_at":"2026-02-04T01:08:02.010Z","avatar_url":"https://github.com/csinva.png","language":"AMPL","funding_links":[],"categories":[],"sub_categories":[],"readme":"# axon simulations\n- tapering axon simulation code based on Johnson, Holmes, Brown, and Jung 2015\n\n# setup\n## run the code\n- clone the repo\n- compile the mod files (differs based on OS - see NEURON documentation)\n- run main.hoc\n\n# todo\n\n# reference\n## goals\n1. maximize velocity\n2. minimize energy\n3. minimize noise variability\n\n## constraints\n- amount of protein membrane can sustain\n\n### hypotheses\n- node only gets to minimum needed\n\t- see brill et al ~1997\n- Resting potential might be getting messed up\n- Look at changing gbar\n- Look at changing potassium conductances\n\n## notes\n- currently fires with noise\n\t- fires at very low voltage\n- Johnson, Holmes, Brown, and Jung 2015\n\t- Goal: maximize conduction velocity but minimize metabolic costs\n\t- Myelination does this by decreasing capacitance\n\t- Increasing axon diameter does this by increasing ion flow\n\t- They assume fixed number of sodium channels and change morphology\n\t- 3 different taperings along the PARA\n- other papers\n\t- base on Mcintyre, Richardson, and Grill 2001\n\t- empirical fits to blight, 1985 rat recording and david, 1995 rat recording\n\n\t\n## done\n- fixed surface area and looked at different diameters","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fcsinva%2Faxon-ap-propagation","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fcsinva%2Faxon-ap-propagation","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fcsinva%2Faxon-ap-propagation/lists"}