{"id":17099095,"url":"https://github.com/dhimmel/erc","last_synced_at":"2025-07-23T11:34:22.963Z","repository":{"id":30869230,"uuid":"34426843","full_name":"dhimmel/erc","owner":"dhimmel","description":"Processing human Evolutionary Rate Covariation data","archived":false,"fork":false,"pushed_at":"2016-03-28T03:55:02.000Z","size":6354,"stargazers_count":1,"open_issues_count":2,"forks_count":0,"subscribers_count":1,"default_branch":"gh-pages","last_synced_at":"2025-03-23T18:12:49.768Z","etag":null,"topics":["data","erc","evolution","evolutionary-rate-covariation","genes","hetionet","human","rephetio"],"latest_commit_sha":null,"homepage":"https://doi.org/10.15363/thinklab.d57","language":"Jupyter Notebook","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":null,"status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/dhimmel.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":null,"code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null}},"created_at":"2015-04-23T01:42:47.000Z","updated_at":"2019-11-09T03:51:05.000Z","dependencies_parsed_at":"2022-09-06T23:51:44.143Z","dependency_job_id":null,"html_url":"https://github.com/dhimmel/erc","commit_stats":null,"previous_names":[],"tags_count":1,"template":false,"template_full_name":null,"purl":"pkg:github/dhimmel/erc","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2Ferc","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2Ferc/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2Ferc/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2Ferc/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/dhimmel","download_url":"https://codeload.github.com/dhimmel/erc/tar.gz/refs/heads/gh-pages","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2Ferc/sbom","host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":266669529,"owners_count":23965760,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2022-07-04T15:15:14.044Z","status":"online","status_checked_at":"2025-07-23T02:00:09.312Z","response_time":66,"last_error":null,"robots_txt_status":null,"robots_txt_updated_at":null,"robots_txt_url":"https://github.com/robots.txt","online":true,"can_crawl_api":true,"host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["data","erc","evolution","evolutionary-rate-covariation","genes","hetionet","human","rephetio"],"created_at":"2024-10-14T15:09:00.322Z","updated_at":"2025-07-23T11:34:22.940Z","avatar_url":"https://github.com/dhimmel.png","language":"Jupyter Notebook","funding_links":[],"categories":[],"sub_categories":[],"readme":"# Processing human Evolutionary Rate Covariation data\n\nThis resource processes the [evolutionary rate covaration](http://csb.pitt.edu/erc_analysis/Methods.php) (ERC) data from [Priedigkeit et al 2015](https://doi.org/10.1371/journal.pgen.1004967 \"Evolutionary Signatures amongst Disease Genes Permit Novel Methods for Gene Prioritization and Construction of Informative Gene-Based Networks\"). ERC assesses whether two genes have a similar evolutionary history. See the corresponding [Thinklab discussion](http://doi.org/10.15363/thinklab.d57 \"Selecting informative ERC (evolutionary rate covariation) values between genes\") for more information.\n\n## Files\n\n`erc.ipynb` converts the raw ERC data into a tidy TSV (`erc_mam33.tsv.gz`) containing each gene pair mapped to Entrez Gene. `entrez-group.R` converts to using Entrez Gene as the primary gene identifiers. `erc_mam33-entrez.tsv.gz` is not tracked, since it's 821 MB, but the subset of gene pairs with ERC values \u003e= 0.6 is stored in `erc_mam33-entrez-gt-0.6.tsv.gz`. \n\n## License\n\nAll original content in this repository is licensed under [CC0 1.0](https://creativecommons.org/publicdomain/zero/1.0/ \"CC0 1.0 Universal: Public Domain Dedication\"). ERC data is used with permission.\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fdhimmel%2Ferc","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fdhimmel%2Ferc","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fdhimmel%2Ferc/lists"}