{"id":17099163,"url":"https://github.com/dhimmel/sider2","last_synced_at":"2025-08-24T19:06:49.605Z","repository":{"id":26600013,"uuid":"30054933","full_name":"dhimmel/SIDER2","owner":"dhimmel","description":"Calculating compound similarities using side effects and indications extracted from drug labels","archived":false,"fork":false,"pushed_at":"2015-02-07T23:28:29.000Z","size":164236,"stargazers_count":3,"open_issues_count":1,"forks_count":6,"subscribers_count":5,"default_branch":"master","last_synced_at":"2025-04-09T16:06:39.713Z","etag":null,"topics":["compound","drug","side-effect","sider","sider2"],"latest_commit_sha":null,"homepage":"http://git.dhimmel.com/SIDER2/","language":"TeX","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":"cc0-1.0","status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/dhimmel.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":"LICENSE.md","code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null}},"created_at":"2015-01-30T03:47:24.000Z","updated_at":"2023-06-24T04:30:41.000Z","dependencies_parsed_at":"2022-08-17T17:30:44.622Z","dependency_job_id":null,"html_url":"https://github.com/dhimmel/SIDER2","commit_stats":null,"previous_names":[],"tags_count":0,"template":false,"template_full_name":null,"repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2FSIDER2","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2FSIDER2/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2FSIDER2/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/dhimmel%2FSIDER2/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/dhimmel","download_url":"https://codeload.github.com/dhimmel/SIDER2/tar.gz/refs/heads/master","host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":248065286,"owners_count":21041871,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2022-07-04T15:15:14.044Z","host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["compound","drug","side-effect","sider","sider2"],"created_at":"2024-10-14T15:09:13.962Z","updated_at":"2025-04-09T16:06:50.980Z","avatar_url":"https://github.com/dhimmel.png","language":"TeX","funding_links":[],"categories":[],"sub_categories":[],"readme":"# SIDER 2\n\nThis repository contains an analysis of the [SIDER 2](http://sideeffects.embl.de/) (**sid**e **e**ffect **r**esource) [data](http://sideeffects.embl.de/download/). This resource automatically extracted concepts from drug labels to create a database of drug side effects and indications.\n\nThis analysis provides the source for a [companion website](http://git.dhimmel.com/SIDER2/), which displays the analysis.\n\nThis project is divided into three parts and each part contains a single notebook:\n\n1. `./parse` -- processing the SIDER 2 data in *R*\n2. `./similarity` -- calculating compound-compound similarities in *R*\n3. `./compounds` -- querying pubchem for compound attributes in *python*\n\nThe SIDER database was described in:\n\n\u003e Kuhn M, Campillos M, Letunic I, Jensen LJ, Bork P (2010) A side effect resource to capture phenotypic effects of drugs. *Molecular Systems Biology*. doi:[10.1038/msb.2009.98](http://dx.doi.org/10.1038/msb.2009.98)\n\nTo compute compound-compound similarity, we use an analysis similar to:\n\n\u003e Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P (2008). Drug Target Identification Using Side-Effect Similarity. *Science* doi:[10.1126/science.1158140](http://dx.doi.org/10.1126/science.1158140)\n\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fdhimmel%2Fsider2","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fdhimmel%2Fsider2","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fdhimmel%2Fsider2/lists"}