{"id":20494746,"url":"https://github.com/fhdsl/anvil_book_epigenetics_intro","last_synced_at":"2025-04-13T17:43:07.681Z","repository":{"id":55389275,"uuid":"523053391","full_name":"fhdsl/AnVIL_Book_Epigenetics_Intro","owner":"fhdsl","description":"An introductory activity for epigenetics, or the idea of \"nature versus nurture\" in genetics. 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The first activity, \"Explore the Epigenome\", leverages the UCSC Genome Browser - a powerful tool for visualizing genomic differences. This book is part of a series of books for the Genomic Data Science Analysis, Visualization, and Informatics Lab-space (AnVIL) of the National Human Genome Research Institute (NHGRI). \n\n## Learning Objectives\n\nThis course will teach learners to:  \n\n- Discuss how DNA is packaged in the chromosomes in terms of histones, nucleosomes, and chromatin.\n- Defend how most cells can have the same genetic content and yet have different functions in the body.\n- Contrast the packaging of DNA into euchromatin versus heterochromatin in the context of histone modification, and DNA modification (where applicable).\n- Discuss the potential roles of DNA modification, histone modification, and non-coding RNA in epigenetic inheritance, both somatic and germline.\n- Discuss environmental impacts on epigenetic systems.\n- Describe how differential histone modification modulates gene activity and is utilized in developmental progression.\n\nLearning objectives for this activity come from the [Genetics Core Competencies](https://genetics-gsa.org/education/genetics-learning-framework/).\n\n## Encountering problems?\n\nIf you are encountering any problems with this course, please file a GitHub issue or contact Ava Hoffman (ahoffma2 at fredhutch.org).\n\n\u003ca rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\"\u003e\u003cimg alt=\"Creative Commons License\" style=\"border-width:0\" src=\"https://i.creativecommons.org/l/by/4.0/88x31.png\" /\u003e\u003c/a\u003e\u003cbr /\u003eAll materials in this course are licensed under a \u003ca rel=\"license\" href=\"http://creativecommons.org/licenses/by/4.0/\"\u003eCreative Commons Attribution 4.0 International License\u003c/a\u003e unless noted otherwise.\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Ffhdsl%2Fanvil_book_epigenetics_intro","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Ffhdsl%2Fanvil_book_epigenetics_intro","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Ffhdsl%2Fanvil_book_epigenetics_intro/lists"}