{"id":41249658,"url":"https://github.com/ga4gh/vrs","last_synced_at":"2026-02-12T19:07:13.959Z","repository":{"id":40296258,"uuid":"67005248","full_name":"ga4gh/vrs","owner":"ga4gh","description":"Extensible specification for representing and uniquely identifying biological sequence variation","archived":false,"fork":false,"pushed_at":"2025-12-20T21:02:29.000Z","size":9343,"stargazers_count":94,"open_issues_count":34,"forks_count":38,"subscribers_count":24,"default_branch":"v2","last_synced_at":"2025-12-22T14:24:04.880Z","etag":null,"topics":["bioinformatics","genomics","variation"],"latest_commit_sha":null,"homepage":"https://vrs.ga4gh.org","language":"Jupyter Notebook","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":"apache-2.0","status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/ga4gh.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":"CONTRIBUTING.md","funding":null,"license":"LICENSE","code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":".github/CODEOWNERS","security":null,"support":null,"governance":null,"roadmap":null,"authors":null,"dei":null,"publiccode":null,"codemeta":null,"zenodo":null,"notice":null,"maintainers":null,"copyright":null,"agents":null,"dco":null,"cla":null}},"created_at":"2016-08-31T05:09:01.000Z","updated_at":"2025-12-09T12:23:08.000Z","dependencies_parsed_at":"2023-01-28T00:30:59.521Z","dependency_job_id":"56be9522-4fc5-4bd4-a3c7-0f99448ac63c","html_url":"https://github.com/ga4gh/vrs","commit_stats":null,"previous_names":[],"tags_count":28,"template":false,"template_full_name":null,"purl":"pkg:github/ga4gh/vrs","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/ga4gh%2Fvrs","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/ga4gh%2Fvrs/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/ga4gh%2Fvrs/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/ga4gh%2Fvrs/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/ga4gh","download_url":"https://codeload.github.com/ga4gh/vrs/tar.gz/refs/heads/v2","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/ga4gh%2Fvrs/sbom","scorecard":null,"host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":286080680,"owners_count":28677710,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2026-01-23T01:00:35.747Z","status":"ssl_error","status_checked_at":"2026-01-23T01:00:19.529Z","response_time":144,"last_error":"SSL_read: unexpected eof while reading","robots_txt_status":"success","robots_txt_updated_at":"2025-07-24T06:49:26.215Z","robots_txt_url":"https://github.com/robots.txt","online":false,"can_crawl_api":true,"host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["bioinformatics","genomics","variation"],"created_at":"2026-01-23T01:33:46.829Z","updated_at":"2026-01-23T01:33:47.430Z","avatar_url":"https://github.com/ga4gh.png","language":"Jupyter Notebook","funding_links":[],"categories":[],"sub_categories":[],"readme":"# Variation Representation Specification (VRS)\n\n[![DOI](https://zenodo.org/badge/67005248.svg)](https://zenodo.org/badge/latestdoi/67005248)\n[![Read the Docs](https://img.shields.io/readthedocs/vr-spec/1.1)](https://vrs.ga4gh.org/)\n[![tests](https://github.com/ga4gh/vrs/actions/workflows/tests.yml/badge.svg)](https://github.com/ga4gh/vrs/actions/workflows/tests.yml)\n\nThe [GA4GH](https://www.ga4gh.org/) [Variation Representation Specification](https://vrs.ga4gh.org/)\nprovides a comprehensive framework for the computational representation of biological sequence\nvariation. VRS is the result of a collaboration among [contributors](CONTRIBUTORS.md) representing\nnational information resource providers, major international public initiatives, and diagnostic\ntesting laboratories.\n\nVRS is licensed under the [Apache License 2.0](LICENSE).\n\n\u003e **NOTE:** VRS is under active development.\n\u003e See the [VRS Project Roadmap](https://github.com/orgs/ga4gh/projects/12).\n\n## Specific goals\n\n* Develop common language- and protocol-neutral information models and nomenclature for\n  biological sequence variation.\n* From the information models, develop data schemas. The current schema is defined in\n  JSON Schema, but other formats are expected.\n* Provide algorithmic guidance and conventions to minimize representational ambiguity.\n* Define a globally unique *computed identifier* for covered data classes.\n* Develop [validation tests](./validation/) to ensure consistency of implementations.\n\nThe VRS model is the product of the [GA4GH Variation Representation group](https://www.ga4gh.org/product/variation-representation/).\n\n\u003e **SEE ALSO**: See [VRS-Python](https://github.com/ga4gh/vrs-python) for a Python\n\u003e implementation and Jupyter notebooks.\n\n## Using the schema\n\nThe schema is available in the [schema/](./schema/) directory, in both yaml and json versions.\nIt conforms to JSON Schema Draft 2020-12. For a list of\nlibraries that support JSON schema, see\n[JSONSchema\u003eTools](https://json-schema.org/tools).\n\n## Installing for development\n\nFork the repo at \u003chttps://github.com/ga4gh/vrs\u003e.\n\n    git clone --recurse-submodules git@github.com:YOUR_GITHUB_ID/vrs.git\n    cd vrs\n    make devready\n    source venv/3.12/bin/activate\n    pre-commit install\n\nIf you already cloned the repo, but forgot to include `--recurse-submodules` you can run:\n\n    git submodule update --init --recursive\n\n## Contributing to the schema\n\nVRS uses [vrs-source.yaml](./schema/vrs/vrs-source.yaml) as the source document for JSON Schema.\n\nTo create the corresponding def and json files after making changes to the source document, from the root directory:\n\n    cd schema\n    make all\n\n\u003e *Note: We have a custom pre-commit hook to run these commands after you stage a source\n\u003e document*\n\n## Contributing to the docs\n\nThe VRS specification documentation is written in reStructuredText and located in [docs/source](docs/source/). Commits to this repo are built automatically at \u003chttps://vrs.ga4gh.org\u003e.\n\nTo build documentation locally, you must install [entr](https://eradman.com/entrproject/):\n\n    brew install entr\n\nThen from the root directory:\n\n    cd docs\n    make clean watch \u0026\n\nThen, open [docs/build/html/index.html](./docs/build/html/index.html). The above make\ncommand should build docs when source changes. (Some types of changes require recleaning and building.)\n\n## Testing\n\nThe VRS repo contains two kinds of tests. Basic smoke tests in [tests/](./tests/) ensure that the\nschema is parsable and works with certain tools. These tests provide a basic sanity\ncheck during development.\n\nValidation tests (in [validation/](./validation/)) provide language-neutral tests for those implementing\ntools with VRS.\n\nTo run the smoke tests:\n\n    make test\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fga4gh%2Fvrs","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fga4gh%2Fvrs","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fga4gh%2Fvrs/lists"}