{"id":22731119,"url":"https://github.com/genentech/mrgsolve_replace_nmsim","last_synced_at":"2026-07-05T19:31:18.088Z","repository":{"id":72633663,"uuid":"301542943","full_name":"Genentech/mrgsolve_replace_NMsim","owner":"Genentech","description":null,"archived":false,"fork":false,"pushed_at":"2020-10-05T22:31:27.000Z","size":2558,"stargazers_count":0,"open_issues_count":0,"forks_count":0,"subscribers_count":3,"default_branch":"main","last_synced_at":"2025-10-28T02:47:29.012Z","etag":null,"topics":[],"latest_commit_sha":null,"homepage":"https://genentech.github.io/mrgsolve_replace_NMsim/01_mrgsolve_replace_NMsim.html","language":"C++","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":"mit","status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/Genentech.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":"LICENSE.txt","code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null,"roadmap":null,"authors":null,"dei":null,"publiccode":null,"codemeta":null}},"created_at":"2020-10-05T21:21:36.000Z","updated_at":"2025-02-27T19:09:56.000Z","dependencies_parsed_at":null,"dependency_job_id":"8f7a007e-ca3f-419e-b2fa-47aee33f5c86","html_url":"https://github.com/Genentech/mrgsolve_replace_NMsim","commit_stats":null,"previous_names":[],"tags_count":0,"template":false,"template_full_name":null,"purl":"pkg:github/Genentech/mrgsolve_replace_NMsim","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Genentech%2Fmrgsolve_replace_NMsim","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Genentech%2Fmrgsolve_replace_NMsim/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Genentech%2Fmrgsolve_replace_NMsim/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Genentech%2Fmrgsolve_replace_NMsim/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/Genentech","download_url":"https://codeload.github.com/Genentech/mrgsolve_replace_NMsim/tar.gz/refs/heads/main","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Genentech%2Fmrgsolve_replace_NMsim/sbom","scorecard":null,"host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":286080680,"owners_count":35167259,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2026-05-26T15:22:16.424Z","status":"online","status_checked_at":"2026-07-05T02:00:06.290Z","response_time":100,"last_error":null,"robots_txt_status":"success","robots_txt_updated_at":"2025-07-24T06:49:26.215Z","robots_txt_url":"https://github.com/robots.txt","online":true,"can_crawl_api":true,"host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":[],"created_at":"2024-12-10T19:19:29.899Z","updated_at":"2026-07-05T19:31:18.060Z","avatar_url":"https://github.com/Genentech.png","language":"C++","funding_links":[],"categories":[],"sub_categories":[],"readme":"# mrgsolve_replace_NMsim\nPurpose: use mrgsolve to replace `$SIM` and `vpc` with NONMEM/psn\n\nThe main motivation is to avoid using NONMEM for any simulation tasks (and associated dataset generation \u0026 CSV handling), so that the only NONMEM run you would do is $EST.  \nYou still need to develop `mrgsolve` model file, but from my experience that effort will pays off quite immediately.  \n\n\n## Quick look\n\nSee https://genentech.github.io/mrgsolve_replace_NMsim/01_mrgsolve_replace_NMsim.html for output from the RMarkdown template\n\n\n## How to use\n\nYou can download this repository from the green `Clone or download` button on top right.  \nOnce cloned or unarchived the ZIP file, you can double-click \"mrgsolve_replace_NMsim.Rproj\" to open this repository in RStudio. \n\nThe main RMarkdown template file is `script/01_mrgsolve_replace_NMsim.Rmd`, which should be directly executable once you install all the necessary R packages from CRAN.\n\n\n## Author\n\nThis tool was initiated by Kenta Yoshida (yoshida.kenta@gene.com) within Genentech Clinical Pharmacology Department.\n\n\n## License \n\nThe source code is distributed under a MIT license. Full description can be found in [LICENSE.txt](LICENSE.txt)\n\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fgenentech%2Fmrgsolve_replace_nmsim","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fgenentech%2Fmrgsolve_replace_nmsim","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fgenentech%2Fmrgsolve_replace_nmsim/lists"}