{"id":39554211,"url":"https://github.com/jackhump/fus_intron_retention","last_synced_at":"2026-01-18T07:00:44.744Z","repository":{"id":185141751,"uuid":"173825581","full_name":"jackhump/FUS_intron_retention","owner":"jackhump","description":"Scripts written for the FUS NLS mutation comparison with FUS KO project","archived":false,"fork":false,"pushed_at":"2020-06-08T16:44:31.000Z","size":62,"stargazers_count":1,"open_issues_count":0,"forks_count":0,"subscribers_count":3,"default_branch":"master","last_synced_at":"2023-10-20T20:31:58.349Z","etag":null,"topics":[],"latest_commit_sha":null,"homepage":null,"language":"R","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":null,"status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/jackhump.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":null,"code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null}},"created_at":"2019-03-04T21:39:07.000Z","updated_at":"2020-06-08T16:44:34.000Z","dependencies_parsed_at":null,"dependency_job_id":"7c01a0ae-f3c9-48ae-acc5-c699a2a45a5a","html_url":"https://github.com/jackhump/FUS_intron_retention","commit_stats":null,"previous_names":["jackhump/fus_intron_retention"],"tags_count":0,"template":null,"template_full_name":null,"purl":"pkg:github/jackhump/FUS_intron_retention","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jackhump%2FFUS_intron_retention","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jackhump%2FFUS_intron_retention/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jackhump%2FFUS_intron_retention/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jackhump%2FFUS_intron_retention/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/jackhump","download_url":"https://codeload.github.com/jackhump/FUS_intron_retention/tar.gz/refs/heads/master","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jackhump%2FFUS_intron_retention/sbom","scorecard":null,"host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":286080680,"owners_count":28532579,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2026-01-18T00:39:45.795Z","status":"online","status_checked_at":"2026-01-18T02:00:07.578Z","response_time":98,"last_error":null,"robots_txt_status":"success","robots_txt_updated_at":"2025-07-24T06:49:26.215Z","robots_txt_url":"https://github.com/robots.txt","online":true,"can_crawl_api":true,"host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":[],"created_at":"2026-01-18T07:00:23.913Z","updated_at":"2026-01-18T07:00:44.734Z","avatar_url":"https://github.com/jackhump.png","language":"R","funding_links":[],"categories":[],"sub_categories":[],"readme":"# *FUS* ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention\n\n**Jack Humphrey**\n\n[paper now published at Nucleic Acids Research](https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa410/5849905)\n\nAll code written in R and presented as Rmarkdown documents for readability.\n\nAccompanying scripts:\n\n#### 01_differential_expression/\n- 01_DESeq_joint_modelling.Rmd\n- 02_iCLIP_gene_expression.Rmd\n#### 02_differential_splicing/\n- 01_SGSeq_joint_modelling.Rmd\n- 02_SGSeq_variant_function.Rmd\n- 03_SGSeq_plotting.Rmd\n- 04_compare_expression_splicing.Rmd\n#### 03_autoregulation/\n- 01_FUS_intron_retention_plotting.Rmd\n- 02_Autoregulation_validation.Rmd\n#### 04_comparing_other_data/\n- 01_TDP_cross_regulation.Rmd\n- 02_Luisier_VCP_cross_regulation.Rmd\n#### 05_heterozygotes/\n- Comparing_Hets.Rmd\n#### 06_CLIPdb_FUS_introns/\n- retained_intron_clip.R\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fjackhump%2Ffus_intron_retention","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fjackhump%2Ffus_intron_retention","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fjackhump%2Ffus_intron_retention/lists"}