{"id":16520833,"url":"https://github.com/jhrcook/comutation-manuscript","last_synced_at":"2025-03-03T01:15:51.196Z","repository":{"id":115870059,"uuid":"228924600","full_name":"jhrcook/comutation-manuscript","owner":"jhrcook","description":"Manuscript for the KRAS comutation research project.","archived":false,"fork":false,"pushed_at":"2020-06-22T13:46:15.000Z","size":39483,"stargazers_count":0,"open_issues_count":0,"forks_count":0,"subscribers_count":1,"default_branch":"master","last_synced_at":"2025-01-13T11:50:09.257Z","etag":null,"topics":["cancer","cancer-genetics","comutation","haigis","haigis-lab","kras","krasalleles","latex","manuscript","overleaf"],"latest_commit_sha":null,"homepage":"https://github.com/jhrcook/comutation","language":"TeX","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":null,"status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/jhrcook.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":null,"code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null,"roadmap":null,"authors":null}},"created_at":"2019-12-18T21:29:19.000Z","updated_at":"2022-10-25T14:04:15.000Z","dependencies_parsed_at":null,"dependency_job_id":"2abfce7a-b692-4675-955c-02b78ef4a679","html_url":"https://github.com/jhrcook/comutation-manuscript","commit_stats":{"total_commits":67,"total_committers":1,"mean_commits":67.0,"dds":0.0,"last_synced_commit":"fae04e64605fbf92a1acb12bbc2f3cbd79a0a52e"},"previous_names":[],"tags_count":5,"template":false,"template_full_name":null,"repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jhrcook%2Fcomutation-manuscript","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jhrcook%2Fcomutation-manuscript/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jhrcook%2Fcomutation-manuscript/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/jhrcook%2Fcomutation-manuscript/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/jhrcook","download_url":"https://codeload.github.com/jhrcook/comutation-manuscript/tar.gz/refs/heads/master","host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":241592151,"owners_count":19987311,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2022-07-04T15:15:14.044Z","host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["cancer","cancer-genetics","comutation","haigis","haigis-lab","kras","krasalleles","latex","manuscript","overleaf"],"created_at":"2024-10-11T16:53:21.663Z","updated_at":"2025-03-03T01:15:51.167Z","avatar_url":"https://github.com/jhrcook.png","language":"TeX","funding_links":[],"categories":[],"sub_categories":[],"readme":"# KRAS comutation manuscript\n\nJoshua Cook, Giorgio Melloni, Peter J. Park ([lab](https://compbio.hms.harvard.edu/index)), Kevin M. Haigis ([lab](https://www.haigislab.org))\n\n## Abstract\n\nMutational activation of the *KRAS* oncogene promotes initiation and/or progression of cancer in a variety of tissues.\nThough the mutant variants seemingly exert similar biological outputs, the biochemical properties and downstream signaling  of each is distinct and highly context-dependent.\nAs such, the genetic interactions associated with *KRAS* mutants are likely to vary according to the specific allele and the tissue-of-origin of the cancer.\nTo explore this concept, 13,492 samples were collated from four tumor types with the highest frequency of mutation in *KRAS*: colorectal adenocarcinoma, lung adenocarcinoma, multiple myeloma, and pancreatic adenocarcinoma.\nEach cancer had a distinct spectrum of *KRAS* activating mutations that could not be predicted by the prevalence of known mutagenic mechanisms.\nMoreover, each allele was associated with a distinct comutation network that was also tissue-specific.\nAnalyzing genetic dependencies highlighted cellular functions and individual genes that were or were not required for tumors with specific *KRAS* alleles.\nOverall, this analysis demonstrates that the *KRAS* alleles have distinct genetic interactions likely linked to their biological differences that can be further investigated as therapeutic targets.\n\n---\n\n![Build LaTeX document](https://github.com/jhrcook/comutation-manuscript/workflows/Build%20LaTeX%20document/badge.svg)\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fjhrcook%2Fcomutation-manuscript","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fjhrcook%2Fcomutation-manuscript","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fjhrcook%2Fcomutation-manuscript/lists"}