{"id":24529905,"url":"https://github.com/mschubert/mad2-transposon","last_synced_at":"2025-03-15T18:20:54.270Z","repository":{"id":65608524,"uuid":"108263834","full_name":"mschubert/mad2-transposon","owner":"mschubert","description":"Analysis code for \"Cancer tolerance to chromosomal instability is driven by Stat1 inactivation in vivo\"","archived":false,"fork":false,"pushed_at":"2024-02-04T19:01:18.000Z","size":1793,"stargazers_count":0,"open_issues_count":11,"forks_count":0,"subscribers_count":3,"default_branch":"master","last_synced_at":"2025-01-22T07:52:58.287Z","etag":null,"topics":[],"latest_commit_sha":null,"homepage":"https://www.biorxiv.org/content/10.1101/2021.12.03.471107v2","language":"R","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":null,"status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/mschubert.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":null,"code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null,"roadmap":null,"authors":null,"dei":null}},"created_at":"2017-10-25T12:00:06.000Z","updated_at":"2024-02-06T15:17:43.000Z","dependencies_parsed_at":"2024-02-04T20:46:29.323Z","dependency_job_id":null,"html_url":"https://github.com/mschubert/mad2-transposon","commit_stats":null,"previous_names":[],"tags_count":0,"template":false,"template_full_name":null,"repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/mschubert%2Fmad2-transposon","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/mschubert%2Fmad2-transposon/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/mschubert%2Fmad2-transposon/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/mschubert%2Fmad2-transposon/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/mschubert","download_url":"https://codeload.github.com/mschubert/mad2-transposon/tar.gz/refs/heads/master","host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":243770836,"owners_count":20345354,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2022-07-04T15:15:14.044Z","host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":[],"created_at":"2025-01-22T07:53:02.850Z","updated_at":"2025-03-15T18:20:54.242Z","avatar_url":"https://github.com/mschubert.png","language":"R","funding_links":[],"categories":[],"sub_categories":[],"readme":"# Analysis code for \"Cancer tolerance to chromosomal instability is driven by Stat1 inactivation _in vivo_\"\n\n\u003e Chromosomal instability is a hallmark of cancer, but also an instigator of\n\u003e aneuploidy-induced stress, reducing cellular fitness. To better understand\n\u003e how cells with CIN adjust to aneuploidy and adopt a malignant fate in vivo,\n\u003e we performed a genome-wide mutagenesis screen in mice. We find that\n\u003e specifically aneuploid tumors inactivate Stat1 signaling in combination with\n\u003e increased Myc activity. By contrast, loss of p53 is common, but not enriched\n\u003e in CIN tumors. Validation in another tissue type confirmed that CIN promotes\n\u003e immune cell infiltration, which is alleviated by Stat1 loss combined with Myc\n\u003e activation, but not with p53 inactivation, or Myc activation alone.\n\u003e Importantly, we find that this mechanism is preserved in human aneuploid\n\u003e cancers. We conclude that aneuploid cancers inactivate Stat1 signaling to\n\u003e circumvent immune surveillance.\n\nhttps://www.biorxiv.org/content/10.1101/2021.12.03.471107v2\n\nThis repository contains all analysis code, but we are still in the process of\ncleaning it up and properly documenting it.\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fmschubert%2Fmad2-transposon","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fmschubert%2Fmad2-transposon","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fmschubert%2Fmad2-transposon/lists"}