{"id":29625240,"url":"https://github.com/novartis/mvac50","last_synced_at":"2025-07-21T06:07:44.480Z","repository":{"id":146943437,"uuid":"205800735","full_name":"Novartis/mvAC50","owner":"Novartis","description":"AC50 potencies from multivariate assay readouts like gene signatures","archived":false,"fork":false,"pushed_at":"2020-06-19T17:23:52.000Z","size":1224,"stargazers_count":2,"open_issues_count":0,"forks_count":0,"subscribers_count":3,"default_branch":"master","last_synced_at":"2024-04-16T11:10:09.805Z","etag":null,"topics":[],"latest_commit_sha":null,"homepage":null,"language":"R","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":"apache-2.0","status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/Novartis.png","metadata":{"files":{"readme":"README.md","changelog":null,"contributing":null,"funding":null,"license":"LICENSE.txt","code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null}},"created_at":"2019-09-02T07:30:04.000Z","updated_at":"2024-01-05T15:16:55.000Z","dependencies_parsed_at":"2023-04-04T17:31:36.858Z","dependency_job_id":null,"html_url":"https://github.com/Novartis/mvAC50","commit_stats":null,"previous_names":[],"tags_count":0,"template":false,"template_full_name":null,"purl":"pkg:github/Novartis/mvAC50","repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Novartis%2FmvAC50","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Novartis%2FmvAC50/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Novartis%2FmvAC50/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Novartis%2FmvAC50/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/Novartis","download_url":"https://codeload.github.com/Novartis/mvAC50/tar.gz/refs/heads/master","sbom_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/Novartis%2FmvAC50/sbom","host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":266248501,"owners_count":23899056,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2022-07-04T15:15:14.044Z","host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":[],"created_at":"2025-07-21T06:07:43.935Z","updated_at":"2025-07-21T06:07:44.474Z","avatar_url":"https://github.com/Novartis.png","language":"R","funding_links":[],"categories":[],"sub_categories":[],"readme":"# mvAC50 - AC50 potencies from multivariate assay readouts like gene signatures\n\nmvAC50 is an R package for the calculation of AC50s (general term for IC50s or EC50s) from multivariate assay readouts, such as gene signatures, measured at multiple concentrations. The R package provides multiple parametric and non-parametric statistical methods to quantify effects of compounds on multivariate readouts, and derive AC50s from those. \n\n\n## Reference\n\nRenner *et al.*, **Gene-signature-derived IC50s/EC50s reflect the potency of causative upstream targets and downstream phenotypes**\nSci Rep. 2020 Jun 15;10(1):9670. doi: 10.1038/s41598-020-66533-5\nhttps://www.nature.com/articles/s41598-020-66533-5\n\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fnovartis%2Fmvac50","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fnovartis%2Fmvac50","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fnovartis%2Fmvac50/lists"}