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variant: gfm\n---\n\n```{r, echo = FALSE}\nknitr::opts_chunk$set(\n  collapse = TRUE,\n  comment = \"#\u003e\",\n  fig.path = \"man/figures/README-\",\n  out.width = \"100%\"\n)\n```\n\n \u003c!-- badges: start --\u003e\n[![](https://www.r-pkg.org/badges/version/rpact)](https://cran.r-project.org/package=rpact) \n[![R-CMD-check](https://github.com/rpact-com/rpact/actions/workflows/R-CMD-check.yaml/badge.svg)](https://github.com/rpact-com/rpact/actions/workflows/R-CMD-check.yaml) \n[![Total downloads](https://cranlogs.r-pkg.org/badges/grand-total/rpact?color=blue)](https://CRAN.R-project.org/package=rpact) \n[![Monthly downloads](https://cranlogs.r-pkg.org/badges/rpact?color=blue)](https://CRAN.R-project.org/package=rpact) \n[![Lifecycle: stable](https://img.shields.io/badge/lifecycle-stable-brightgreen.svg)](https://lifecycle.r-lib.org/articles/stages.html#stable) \n[![License: LGPL v3](https://img.shields.io/badge/License-LGPL_v3-blue.svg)](https://cran.r-project.org/web/licenses/LGPL-3) \n[![Codecov test coverage](https://codecov.io/gh/rpact-com/rpact/branch/main/graph/badge.svg)](https://app.codecov.io/gh/rpact-com/rpact?branch=main)\n[![](https://img.shields.io/badge/DOI-10.1007/978--3--031--89669--9-yellow.svg?logo=doi)](https://doi.org/10.1007/978-3-031-89669-9) \n[![](https://img.shields.io/badge/RPACT-Cloud-blue.svg?logo=r)](https://rpact-cloud.share.connect.posit.cloud)\n[![](https://img.shields.io/badge/RPACT-Connect-669999.svg?labelColor=336699)](https://rpact-connect.share.connect.posit.cloud)\n \u003c!-- badges: end --\u003e\n\n# rpact \u003ca href=\"https://www.rpact.com\"\u003e\u003cimg src=\"man/figures/logo.png\" align=\"right\" height=\"138\" /\u003e\u003c/a\u003e\n\nConfirmatory Adaptive Clinical Trial Design, Simulation, and Analysis.\n\n## Functional Range\n\n*\tFixed sample design and designs with interim analysis stages\n*\tSample size and power calculation for\n    +\tmeans (continuous endpoint)\n    +\trates (binary endpoint)\n    +\tsurvival trials with flexible recruitment and survival time options\n    +\tcount data \n*\tSimulation tool for means, rates, survival data, and count data\n    +\tAssessment of adaptive sample size/event number recalculations based on\n        conditional power\n    +   Assessment of treatment selection strategies in multi-arm trials\n*\tAdaptive analysis of means, rates, and survival data\n*\tAdaptive designs and analysis for multi-arm trials\n*\tAdaptive analysis and simulation tools for enrichment design testing means,\n    rates, and hazard ratios\n*\tAutomatic boundary recalculations during the trial for analysis with alpha\n    spending approach, including under- and over-running\n\n## Installation\n\nInstall the latest CRAN release via\n\n```{r installation_cran, eval=FALSE, include=TRUE, echo=TRUE, results='hide'}\ninstall.packages(\"rpact\")\n```\n\n### Development version\n\nTo use a feature from the development version, you can\ninstall the development version of rpact from\n[GitHub](https://github.com/rpact-com/rpact).\n\n```{r installation_github, eval=FALSE, include=TRUE, echo=TRUE, results='hide'}\n# install.packages(\"pak\")\npak::pak(\"rpact-com/rpact\")\n```\n\n## Documentation\n\nThe documentation is hosted at [www.rpact.org](https://www.rpact.org)\n\n## Vignettes\n\nThe vignettes are hosted at\n[www.rpact.org/vignettes](https://www.rpact.org/vignettes/)\n\n## RPACT Connect \n\nConnecting you to insights, downloads, and premium support:\n[connect.rpact.com](https://rpact-connect.share.connect.posit.cloud)\n\n## The RPACT User Group\n\nThe *rpact project* has an active user group consisting of decision-makers and\nusers from the pharmaceutical industry and CROs, who meet regularly\nand, e.g., discuss best practices.\n\nWe invite you to be part of the *RPACT User Group*: benefit from know-how, shape\nopen source development in Pharma!\n\n## Use on corporate computer systems\n\nPlease [contact](https://www.rpact.com/contact/) us to learn how to use `rpact`\non FDA/GxP-compliant validated corporate computer systems and how to get a copy\nof the formal validation documentation that is customized and licensed for\nexclusive use by your company, e.g., to fulfill regulatory requirements.\nThe validation documentation contains the personal access data for performing\nthe installation qualification with `testPackage()`.\n\n\u003e [www.rpact.com/contact](https://www.rpact.com/contact/)\n\n# About\n\n* **rpact** is a comprehensive validated^[The rpact validation documentation is\n  available exclusively for our customers and supporting members. For more\n  information visit\n  [www.rpact.com/services/sla](https://www.rpact.com/services/service-level-agreement/)] R package\n  for clinical research which\n    + enables the design and analysis of confirmatory adaptive group sequential\n      designs\n    + is a powerful sample size calculator\n    + is a free of charge open-source software licensed under\n      [LGPL-3](https://cran.r-project.org/web/licenses/LGPL-3)\n    + particularly, implements the methods described in the recent monograph by\n      [Wassmer and Brannath (2025)](https://doi.org/10.1007%2F978-3-031-89669-9)\n\n\u003e For more information please visit [www.rpact.org](https://www.rpact.org)\n\n* **RPACT** is a company which offers\n    + enterprise R/Shiny software development services \n    + technical support for the\n      [rpact](https://cran.r-project.org/package=rpact) package\n    + consultancy and user training for scientists using R\n    + validated software solutions and R package development for clinical\n      research\n\n\u003e For more information please visit [www.rpact.com](https://www.rpact.com)\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Frpact-com%2Frpact","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Frpact-com%2Frpact","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Frpact-com%2Frpact/lists"}