{"id":13482978,"url":"https://github.com/usnistgov/mosaic","last_synced_at":"2025-12-14T15:39:40.048Z","repository":{"id":22561896,"uuid":"25903159","full_name":"usnistgov/mosaic","owner":"usnistgov","description":"A modular single-molecule analysis interface","archived":false,"fork":false,"pushed_at":"2023-07-06T23:38:03.000Z","size":322816,"stargazers_count":37,"open_issues_count":10,"forks_count":17,"subscribers_count":12,"default_branch":"master","last_synced_at":"2024-09-18T20:20:58.849Z","etag":null,"topics":["nanopore","python","signal-processing","single-molecule","time-series"],"latest_commit_sha":null,"homepage":"https://pages.nist.gov/mosaic/","language":"Python","has_issues":true,"has_wiki":null,"has_pages":null,"mirror_url":null,"source_name":null,"license":"other","status":null,"scm":"git","pull_requests_enabled":true,"icon_url":"https://github.com/usnistgov.png","metadata":{"files":{"readme":"README.rst","changelog":"CHANGELOG.rst","contributing":null,"funding":null,"license":"LICENSE.rst","code_of_conduct":null,"threat_model":null,"audit":null,"citation":null,"codeowners":null,"security":null,"support":null,"governance":null}},"created_at":"2014-10-29T03:44:21.000Z","updated_at":"2024-03-12T12:38:47.000Z","dependencies_parsed_at":"2022-07-16T14:18:24.285Z","dependency_job_id":"3d97fe47-8d95-4274-8bbe-5c9fea87ada2","html_url":"https://github.com/usnistgov/mosaic","commit_stats":null,"previous_names":[],"tags_count":58,"template":false,"template_full_name":null,"repository_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/usnistgov%2Fmosaic","tags_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/usnistgov%2Fmosaic/tags","releases_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/usnistgov%2Fmosaic/releases","manifests_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories/usnistgov%2Fmosaic/manifests","owner_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners/usnistgov","download_url":"https://codeload.github.com/usnistgov/mosaic/tar.gz/refs/heads/master","host":{"name":"GitHub","url":"https://github.com","kind":"github","repositories_count":222262650,"owners_count":16957618,"icon_url":"https://github.com/github.png","version":null,"created_at":"2022-05-30T11:31:42.601Z","updated_at":"2022-07-04T15:15:14.044Z","host_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub","repositories_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repositories","repository_names_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/repository_names","owners_url":"https://repos.ecosyste.ms/api/v1/hosts/GitHub/owners"}},"keywords":["nanopore","python","signal-processing","single-molecule","time-series"],"created_at":"2024-07-31T17:01:07.191Z","updated_at":"2025-12-14T15:39:39.975Z","avatar_url":"https://github.com/usnistgov.png","language":"Python","funding_links":[],"categories":["\u003ca id=\"tag-science\" href=\"#tag-science\"\u003eScience\u003c/a\u003e"],"sub_categories":[],"readme":".. image:: https://img.shields.io/travis/com/usnistgov/mosaic/master?label=linux\r\n\t\t:target: https://travis-ci.com/github/usnistgov/mosaic\r\n.. image:: https://img.shields.io/travis/com/usnistgov/mosaic/master?label=macOS\r\n\t\t:target: https://travis-ci.com/github/usnistgov/mosaic\r\n.. image:: https://img.shields.io/github/v/release/usnistgov/mosaic\r\n\t\t:target: https://github.com/usnistgov/mosaic\r\n.. image:: https://img.shields.io/pypi/v/mosaic-nist.svg\r\n\t:target: https://pypi.org/project/mosaic-nist/\r\n.. image:: https://img.shields.io/pypi/dm/mosaic-nist\r\n   \t:target: https://pypi.org/project/mosaic-nist/\r\n.. image:: https://codecov.io/gh/usnistgov/mosaic/branch/master/graph/badge.svg\r\n\t:target: https://codecov.io/gh/usnistgov/mosaic  \r\n.. image:: https://img.shields.io/badge/dev-NIST-blue\r\n\t:target: https://www.nist.gov\r\n\t\r\nMOSAIC: A modular single-molecule analysis interface\r\n==================================================================\r\n\r\nMOSAIC is a single molecule analysis toolbox that automatically decodes multi-state nanopore data. By modeling the nanopore system with an equivalent circuit, MOSAIC leverages the transient response of a molecule entering the channel to quantify pore-molecule interactions. In contrast to existing techniques such as ionic current thresholding or Viterbi decoding, this technique allows the estimation of short-lived transient events that are otherwise not analyzed.\r\n\r\nNanometer-scale pores have demonstrated potential use in biotechnology applications, including DNA sequencing, single-molecule force spectroscopy, and single-molecule mass spectrometry. The data modeling and analysis methods implemented in MOSAIC allow for dramatic improvements in the quantification of molecular interactions with the channel in each of these applications.\r\n\r\n**If you use MOSAIC in your work, please cite both papers below:**\r\n\r\n1. `Analytical Chemistry 2016, (88) pp. 11900–11907  \u003chttp://pubs.acs.org/doi/abs/10.1021/acs.analchem.6b03725\u003e`_\r\n2. `ACS Nano 2014, (8) pp. 1547–1553.  \u003chttp://pubs.acs.org/doi/abs/10.1021/nn405761y\u003e`_\r\n\r\nInstallation\r\n==================================================================\r\n\r\nPlease refer to the `Installation \u003chttps://pages.nist.gov/mosaic/html/doc/GettingStarted.html\u003e`_ section of the MOSAIC documentation for details on installation.\r\n\r\nDocumentation\r\n==================================================================\r\n\r\nA PDF version of the MOSAIC documentation can be downloaded `here \u003chttps://github.com/usnistgov/mosaic/raw/nist-pages/latex/MOSAIC.pdf\u003e`_.\r\n\r\nGetting Help\r\n==================================================================\r\n\r\nIf you need help or have questions, please join our mailing list.\r\n\r\nTo subscribe:\r\n\r\n\tVisit `https://groups.google.com/a/list.nist.gov/group/mosaic/ \u003chttps://groups.google.com/a/list.nist.gov/group/mosaic/\u003e`_.\r\n\r\nTo unsubscribe:\r\n\r\n\tEmail `mosaic+unsubscribe@list.nist.gov \u003cmailto:mosaic+unsubscribe@list.nist.gov\u003e`_.\r\n\r\nOnce subscribed, you can send messages by emailing `mosaic@list.nist.gov \u003cmailto:mosaic@list.nist.gov\u003e`_.\r\n\r\nReporting Problems\r\n==================================================================\r\n\r\nReport problems using our `issue tracker \u003chttps://github.com/usnistgov/mosaic/issues\u003e`_ on Github.\r\n\r\nWhat's New?\r\n==================================================================\r\n\r\nRead the `Change Log \u003cCHANGELOG.rst\u003e`_\r\n","project_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fusnistgov%2Fmosaic","html_url":"https://awesome.ecosyste.ms/projects/github.com%2Fusnistgov%2Fmosaic","lists_url":"https://awesome.ecosyste.ms/api/v1/projects/github.com%2Fusnistgov%2Fmosaic/lists"}