https://github.com/astrazeneca/trim21-bioprotac

Bioinformatics data analyses - Fletcher A. et al., Nature Communications 2023, doi: 10.1038/s41467-023-42546-2
https://github.com/astrazeneca/trim21-bioprotac

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Bioinformatics data analyses - Fletcher A. et al., Nature Communications 2023, doi: 10.1038/s41467-023-42546-2

• Host: GitHub
• URL: https://github.com/astrazeneca/trim21-bioprotac
• Owner: AstraZeneca
• License: apache-2.0
• Created: 2023-08-06T22:44:24.000Z (almost 3 years ago)
• Default Branch: master
• Last Pushed: 2023-11-12T19:59:16.000Z (over 2 years ago)
• Last Synced: 2025-12-27T06:47:19.676Z (6 months ago)
• Homepage:
• Size: 65.4 KB
• Stars: 2
• Watchers: 1
• Forks: 0
• Open Issues: 0
• Metadata Files:
  • Readme: README.md
  • Contributing: CONTRIBUTING.md
  • License: LICENSE
  • Authors: AUTHORS.md

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README

          
![Maturity level-0](https://img.shields.io/badge/Maturity%20Level-ML--0-red)

Bioinformatics data analysis code accompanying:

[Fletcher, A., Clift, D., de Vries, E. et al. A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation. Nat Commun 14, 7093 (2023). https://doi.org/10.1038/s41467-023-42546-2](https://www.nature.com/articles/s41467-023-42546-2)

Software requirements:

- R 3.6.0 with libraries: devtools 2.3.2, tidyverse 1.3.0, yaml 2.2.1, data.table 1.13.2, limma 3.42.2, ggplot2 3.3.2, ggrepel 0.9.1, VennDiagram 1.6.20

- Python 3.6.6

To reproduce the data analyses, the figures and tables in the paper, install the software requirements and run the [scripts](code.md)

Release at time of publication: [![DOI](https://zenodo.org/badge/675434986.svg)](https://zenodo.org/badge/latestdoi/675434986)

Any updates will be managed directly using this GitHub page