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https://github.com/averissimo/nlmeode

R script for nlmeODE's paper function calls
https://github.com/averissimo/nlmeode

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R script for nlmeODE's paper function calls

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NLME modelling with differential equations
=======

Written in R - http://www.r-project.org/

Commented script that runs the code in the paper below. This was written to test the code in the paper and as a start point to custom ODEs that I wished to test using nlme.

> install.packages(nlmeODE)
> library(nlmeODE)

The same code can be seen by running the examples in nlmeODE PKPmodels

> help(PKPDmodels)

Documentation for the nlmeODE (R) package: http://cran.r-project.org/web/packages/nlmeODE/nlmeODE.pdf

### Reference:

*Christoffer W. Tornøe, Henrik Agersø, E.Niclas Jonsson, Henrik Madsen, Henrik A. Nielsen*
**Non-linear mixed-effects pharmacokinetic/pharmacodynamic modelling in NLME using differential equations**,
Computer Methods and Programs in Biomedicine, Volume 76, Issue 1, October 2004, Pages 31-40, ISSN 0169-2607,
[http://dx.doi.org/10.1016/j.cmpb.2004.01.001](http://dx.doi.org/10.1016/j.cmpb.2004.01.001). ([Sciencedirect link](http://www.sciencedirect.com/science/article/pii/S0169260704000136))

#### Keywords:
- Non-linear mixed-effects models;
- NLME; nlmeODE;
- Population analysis;
- Pharmacokinetic/pharmacodynamic modelling