https://github.com/bhklab/fluvastatin_terbinafine
https://github.com/bhklab/fluvastatin_terbinafine
Last synced: 3 months ago
JSON representation
- Host: GitHub
- URL: https://github.com/bhklab/fluvastatin_terbinafine
- Owner: bhklab
- Created: 2022-05-13T20:48:45.000Z (about 3 years ago)
- Default Branch: main
- Last Pushed: 2024-12-10T04:46:52.000Z (6 months ago)
- Last Synced: 2024-12-30T03:23:42.093Z (5 months ago)
- Language: R
- Size: 14.3 MB
- Stars: 0
- Watchers: 3
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
Awesome Lists containing this project
README
# Fluvastatin_terbinafine Combo Analysis
## Introduction
This is a project to analyze combo data in this manuscript:
Genome-wide CRISPR Screen Identifies Squalene Epoxidase as a Fluvastatin Sensitizer to Effectively Target the Mevalonate Pathway in Breast Cancer, 2024, Leeuwen et. al..
The script for the analysis is written in R.
----
## Dependencies:
These R packages need to be installed in order to run the analysis script:
- PharmacoGx
- magicaxis
- abind
- robustbase
- Biobase
- synergyfinder (1.8.0)
- ComplexHeatmap
- circlize
- ggplot2
- ggpubr
- reshape
- snowfall
- GSA
- piano
- scales
- ggrepel
- dplyr
- tidyr
- BoutrosLab.plotting.general
- UpSetR
----
## Reproducibility of the Analysis:
- Inside the main directory, there is an R script file named "combo_analysis.R". Running this script will regenerate the combo data and analyses in the manuscript linked above.
**Important Note:** the user needs to set the working directory inside the script file before running it, i.e. setting the working directory to "combo_analysis"