https://github.com/bhklab/mycg9a
https://github.com/bhklab/mycg9a
Last synced: 4 months ago
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- Host: GitHub
- URL: https://github.com/bhklab/mycg9a
- Owner: bhklab
- Created: 2018-05-23T17:30:50.000Z (about 7 years ago)
- Default Branch: master
- Last Pushed: 2018-10-10T14:02:57.000Z (over 6 years ago)
- Last Synced: 2024-12-30T03:23:00.314Z (5 months ago)
- Language: R
- Size: 14.6 MB
- Stars: 0
- Watchers: 4
- Forks: 1
- Open Issues: 0
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Metadata Files:
- Readme: README.md
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README
# MYCG9a
## Introduction
This is a project to regenerate the pharmacogenomics analysis in this paper:
MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis. Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ. Cancer Cell. 2018 Oct 8.
The script for the analysis is written in R.
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## Dependencies:
These R packages need to be installed in order to run the analysis script:
- Biobase
- PharmacoGx
- scales
- piano
- GSA
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## Reproducibility of the Analysis:
- Once the project is downloaded to the user computer, the user needs to navigate to the main directory of the project "MYCG9a-master".
- Inside the main directory, there is an R script file named "Script_MYC_G9a_Figures_pharmacogenomics.R". Running this script will regenerate the full pharmacogenomics analysis related to associating g9a inhibitor response with MYC regulation signatures in this paper.
**Important Note:** the user needs to set the working directory inside the script file before running it, i.e. setting the working directory to "MYCG9a-master"