https://github.com/bhklab/prmt5i_gbm
https://github.com/bhklab/prmt5i_gbm
Last synced: 4 months ago
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- Host: GitHub
- URL: https://github.com/bhklab/prmt5i_gbm
- Owner: bhklab
- Created: 2019-05-30T20:12:03.000Z (about 6 years ago)
- Default Branch: master
- Last Pushed: 2020-11-02T19:46:49.000Z (over 4 years ago)
- Last Synced: 2024-12-30T03:22:12.629Z (6 months ago)
- Language: R
- Size: 295 KB
- Stars: 0
- Watchers: 3
- Forks: 0
- Open Issues: 0
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Metadata Files:
- Readme: README.md
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README
# PRMT5i GBM
## Introduction
This is a project to process sensitivity data in this paper:
A PRMT5 Brain Penetrant Inhibitor Disrupts Growth of a Diversity of Patient-Derived Glioblastoma Stem Cells, 2019, Sachamitr et. al..
The script for the analysis is written in R.
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## Dependencies:
These R packages need to be installed in order to run the analysis script:
- IncucyteDRC
- PharmacoGx
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## Reproducibility of the Analysis:
- Once the project is downloaded to the user computer, the user needs to navigate to the main directory of the project "PRMT5i_GBM-master".
- Inside the main directory, there is an R script file named "PRMT5i_GBM_drug_response_processing.R". Running this script will regenerate the senisitvity data of applying PRMT5i to GBM lines in this paper.
**Important Note:** the user needs to set the working directory inside the script file before running it, i.e. setting the working directory to "PRMT5i_GBM-master"