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https://github.com/bluebrain/atlas-enhancement

Tools to generate flatmaps of brain atlases & code to add barrel and barrel column annotations to Allen Mouse CCFv3
https://github.com/bluebrain/atlas-enhancement

neuroinformatics neuroscience

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Tools to generate flatmaps of brain atlases & code to add barrel and barrel column annotations to Allen Mouse CCFv3

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README

          

> [!WARNING]
> The Blue Brain Project concluded in December 2024, so development has ceased under the BlueBrain GitHub organization.
> Future development will take place at: https://github.com/openbraininstitute/atlas-enhancement

# Enhancement of brain atlases with laminar coordinate systems: Flatmaps and barrel column annotations

This code accompanies the manuscript "Enhancement of brain atlases with laminar coordinate systems: Flatmaps and barrel column annotations" by S. Bolaños-Puchet, A. Teska, et al.

Preprint containing full methods and applications availble on [bioRxiv](https://www.biorxiv.org/content/10.1101/2023.08.24.554204).

Accompanying data available on [Zenodo](https://zenodo.org/doi/10.5281/zenodo.8165004).

## Generation of depth and orientation fields

To generate depth and orientation fields, please refer to the documentation of the following repositories:

* [regiodesics](https://github.com/BlueBrain/regiodesics)
* [atlas-direction-vectors](https://github.com/BlueBrain/atlas-direction-vectors)
* [atlas-placement-hints](https://github.com/BlueBrain/atlas-placement-hints/)

## Flatmapping

Complete workflow to generate flatmaps and perform flatmap-based applications, including visualizing 3D datasets in flat space. For more details, please look at the [README](flatmap/README.md) under `flatmap`.

## Annotation of barrels and barrel columns

Code needed to add barrel cortex annotations to the CCFv3 Allen Atlas at 10 $\mu m$ resolution. For more details, please look at the [README](barrel-annotations/README.md) under `barrel-annotations`.

## Citation

If you use the ``atlas-enhancement`` code or method for your research, we ask you to [cite](https://www.biorxiv.org/content/10.1101/2023.08.24.554204):

> Bolaños-Puchet S., Teska A., et al. (2024). Enhancement of brain atlases with laminar coordinate systems: Flatmaps and barrel column annotations. bioRxiv. DOI: 10.1101/2023.08.24.554204

## Funding & Acknowledgments

This project/research was supported by funding to the Blue Brain Project, a research center of the École polytechnique fédérale de Lausanne (EPFL), from the Swiss government’s ETH Board of the Swiss Federal Institutes of Technology.

Copyright (c) 2020-2024 Blue Brain Project/EPFL.

## License

This work is licensed under the Apache License, Version 2.0.