https://github.com/calabrialab/RISingVIS
https://github.com/calabrialab/RISingVIS
Last synced: 13 days ago
JSON representation
- Host: GitHub
- URL: https://github.com/calabrialab/RISingVIS
- Owner: calabrialab
- License: cc-by-4.0
- Created: 2022-05-30T09:29:31.000Z (almost 3 years ago)
- Default Branch: master
- Last Pushed: 2023-06-21T15:10:46.000Z (almost 2 years ago)
- Last Synced: 2024-11-02T16:08:19.146Z (5 months ago)
- Language: R
- Size: 713 KB
- Stars: 1
- Watchers: 3
- Forks: 0
- Open Issues: 0
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Metadata Files:
- Readme: README.md
- Changelog: NEWS.md
- License: LICENSE.md
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- jimsghstars - calabrialab/RISingVIS - (R)
README
# RISingVIS 
The R package RISingVIS was developed to (1) identify, (2) analyze,
through the use of different functions that compute statistics to assess
and quantify their presence, and (3) remove index switching events
in vector integration sites, that can be misleading for further analysis.
In the field of gene therapy vector integration sites (IS) are used as
molecular barcodes for clonal tracking in vivo. IS analysis is required
to assess the safety and efficacy of the treatment, as well for tracking
studies in which they are fundamental to make various calculations.
These IS studies rely on high-throughput sequencing of DNA fragments and
they can be affected by the phenomenon called Index Switching: a molecular
“error” during the sequencing process that may cause mis-assignment
of a fragment to the wrong sample and thus creating false positives.