https://github.com/christianholland/cirrhosis-metabolism
https://github.com/christianholland/cirrhosis-metabolism
bioinformatics liver metabolism transcriptomics
Last synced: 3 months ago
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- Host: GitHub
- URL: https://github.com/christianholland/cirrhosis-metabolism
- Owner: christianholland
- License: gpl-3.0
- Created: 2022-10-18T17:09:39.000Z (over 2 years ago)
- Default Branch: master
- Last Pushed: 2023-09-28T18:28:30.000Z (over 1 year ago)
- Last Synced: 2025-01-22T07:52:57.563Z (5 months ago)
- Topics: bioinformatics, liver, metabolism, transcriptomics
- Language: R
- Homepage: https://christianholland.github.io/cirrhosis-metabolism
- Size: 10.8 MB
- Stars: 0
- Watchers: 1
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
- License: LICENSE
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README
# Cirrhosis Metabolism
Reproducibility of all analyses is ensured by the R package [workflowr](https://github.com/workflowr/workflowr) by deploying all analysis
scripts at a dedicated [website](https://christianholland.github.io/cirrhosis-metabolism).
## About
In this project the expression of genes involved in the metabolism of
xenobiotic substances is analyzed in a mouse model that develops chronic liver
disease induced by administration of CCl~4~ for 2, 6 and 12 months. In addition
their expression in mouse is compared against the expression in patients that
suffer from chronic liver disease utilizing a set of publicly available patient
cohorts (see Table 1 in [this publication](https://aasldpubs.onlinelibrary.wiley.com/doi/10.1002/hep4.1797#hep41797-tbl-0001)
for more details)
The focus is on the following gene families:
* Phase I Metabolism
+ Cytochrome p450 dependent monooxygenase (CYP)
+ Flavin dependent monooxygenases (FMO)
+ Monoamine oxidase (MAO)
+ Cyclooxgenase (COX)
+ Dihydrodioldehydrogenase (DH)
+ DT-Diaphorase (NQOR)
+ Alcohol- and Aldehyddehydrogenase (ADH/ALDH)
+ Epoxidhydrolase (EPH)
* Phase II Metabolism
+ Glutathiontransferase (GST)
+ UDP-glucuronosyltransferase (UGT)
+ Sulfotransferase (SULT)
+ Acetyltransferase (NAT)
+ Methyltransferase (MT)
* Carrier
+ Blood side
+ Canalicular side