Ecosyste.ms: Awesome
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https://github.com/danielbodnar/awesome-nac
A curated list for awesome N-Acetylcysteine (N.A.C.) studies & sources
https://github.com/danielbodnar/awesome-nac
List: awesome-nac
health healthcare n-acetylcysteine nac science-research supplements
Last synced: 2 months ago
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A curated list for awesome N-Acetylcysteine (N.A.C.) studies & sources
- Host: GitHub
- URL: https://github.com/danielbodnar/awesome-nac
- Owner: DanielBodnar
- License: gpl-3.0
- Created: 2020-02-17T17:45:54.000Z (over 4 years ago)
- Default Branch: master
- Last Pushed: 2020-03-14T04:55:44.000Z (over 4 years ago)
- Last Synced: 2024-05-23T06:01:45.451Z (6 months ago)
- Topics: health, healthcare, n-acetylcysteine, nac, science-research, supplements
- Size: 43.9 KB
- Stars: 11
- Watchers: 3
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
- License: LICENSE
Awesome Lists containing this project
README
Awesome-NAC
=======================================================================
[](https://github.com/sindresorhus/awesome)
[](http://creativecommons.org/licenses/by-nc/4.0/)
A curated list for awesome N-Acetylcysteine (N.A.C.) studies & sources
## Description
N-acetyl cysteine (NAC), as a nutritional supplement, is a greatly applied antioxidant in vivo and in vitro. NAC is a precursor of L-cysteine that results in glutathione elevation biosynthesis. It acts directly as a scavenger of free radicals, especially oxygen radicals. NAC is a powerful antioxidant. It is also recommended as a potential treatment option for different disorders resulted from generation of free oxygen radicals. Additionally, it is a protected and endured mucolytic drug that mellows tenacious mucous discharges. It has been used for treatment of various diseases in a direct action or in a combination with some other medications.
## Research Studies by Use or Category
### Overview / Summaries
- [A Review on Various Uses of N-Acetyl Cysteine](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/)
- [Top 9 Benefits of NAC (N-Acetyl Cysteine)](https://www.healthline.com/nutrition/nac-benefits#section10)
### Antioxidant
- [S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans](https://www.ncbi.nlm.nih.gov/pubmed/24835770)
- [Mechanisms underlying the cardioprotective effect of L-cysteine](https://www.ncbi.nlm.nih.gov/pubmed/16132711)
### Detoxification and treatment of Liver & Kidney Damage
- [Cysteine metabolism and metal toxicity](https://www.ncbi.nlm.nih.gov/pubmed/9727078)
- [A Review on Various Uses of N-Acetyl Cysteine](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/)
- [Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine](https://www.ncbi.nlm.nih.gov/pubmed/26694382)
### Mental Health, Psychiatric Disorders, and Additive Behaviors
#### Psychiatric
- [Glutamate - Neuroscience Bookshelf](https://www.ncbi.nlm.nih.gov/books/NBK10807/)
- [The chemistry and biological activities of N-acetylcysteine - ScienceDirect](https://www.sciencedirect.com/science/article/abs/pii/S030441651300144X)
- [N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/)
- [N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis](https://www.ncbi.nlm.nih.gov/pubmed/27137430)
- [N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial](https://www.ncbi.nlm.nih.gov/pubmed/26931055)
- [Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment](https://www.ncbi.nlm.nih.gov/pubmed/27163208)
- [N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study](https://www.ncbi.nlm.nih.gov/pubmed/19581567)
- [N-Acetylcysteine (NAC) in Young Marijuana Users: An Open-Label Pilot Study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826714/)
- [Potential Role of N -Acetylcysteine in the Management of Substance Use Disorders | SpringerLink](https://link.springer.com/article/10.1007%2Fs40263-014-0142-x)
- [The promise of N-acetylcysteine in neuropsychiatry](https://www.ncbi.nlm.nih.gov/pubmed/23369637)
- [Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive ..](https://www.ncbi.nlm.nih.gov/pubmed/27117852)
- [The role for N-acetylcysteine in the management of COPD](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706612/)
#### Alzheimer's disease
- [A Review on Various Uses of N-Acetyl Cysteine: Alzheimer](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/#__sec12title)
- [Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts](https://www.ncbi.nlm.nih.gov/pubmed/17917164)
- [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129149/](https://www.ncbi.nlm.nih.gov/pubmed/18500954/)
#### Parkinson's disease
- [A Review on Various Uses of N-Acetyl Cysteine: Parkinson](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/#__sec13title)
- [N-acetyl-cysteine in the treatment of Parkinson's disease. What are we waiting for?](https://www.ncbi.nlm.nih.gov/pubmed/22546753/)
- [Targeting α-synuclein for treatment of Parkinson's disease: mechanistic and therapeutic considerations.](https://www.ncbi.nlm.nih.gov/pubmed/26050140/)
### Respiratory
- [Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive ..](https://www.ncbi.nlm.nih.gov/pubmed/27117852)
- [The role for N-acetylcysteine in the management of COPD](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706612/)
- [Effect of High/Low Dose N-Acetylcysteine on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis: COPD: Journal of Chronic Obstructive Pulmonary Disease: Vol 11, No 3](https://www.tandfonline.com/doi/abs/10.3109/15412555.2013.858315)
- [N-acetylcysteine in COPD: why, how, and when?](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744393/)
- [Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clin..](https://www.ncbi.nlm.nih.gov/pubmed/10743980)
- [[N-acetylcystein in the therapy of chronic bronchitis]](https://www.ncbi.nlm.nih.gov/pubmed/12486618)
- [The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review | European Respiratory Society ](https://erj.ersjournals.com/content/16/2/253.short)
- [High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450222/)
### Fertility & Birth complications
- [The role of antioxidant therapy in the treatment of male infertility: an overview](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739574/)
- [A Preliminary Study: N-acetyl-L-cysteine Improves Semen Quality following Varicocelectomy](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845522/)
- [Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study](https://www.ncbi.nlm.nih.gov/pubmed/19091331)
- [N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial](https://www.ncbi.nlm.nih.gov/pubmed/17364286)
### Blood sugar, Diabetes & fat cells
- [The molecular basis for oxidative stress-induced insulin resistance](https://www.ncbi.nlm.nih.gov/pubmed/15998259)
- [L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-kappaB activation in the liv..](https://www.ncbi.nlm.nih.gov/pubmed/19328229)
- [N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders](https://www.ncbi.nlm.nih.gov/pubmed/27161488)
- [N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition](https://www.ncbi.nlm.nih.gov/pubmed/26242742)
### Heart & Cardiovascular health
- [N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition](https://www.ncbi.nlm.nih.gov/pubmed/26242742)
- [N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets](https://www.ncbi.nlm.nih.gov/pubmed/11380598)
- [Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein](https://www.ncbi.nlm.nih.gov/pubmed/11755158)
### Immune Function
- [Glutathione and immune function](https://www.ncbi.nlm.nih.gov/pubmed/11115795)
- [HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine](https://www.ncbi.nlm.nih.gov/pubmed/1378279)
- [Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine](https://www.ncbi.nlm.nih.gov/pubmed/1418777)
- [Influence of glutathione availability on cell damage induced by human immunodeficiency virus type 1 viral protein R](https://www.ncbi.nlm.nih.gov/pubmed/26597719)
- [N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N..](https://www.ncbi.nlm.nih.gov/pubmed/19732754)
- [N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway](https://www.ncbi.nlm.nih.gov/pubmed/19722195)
- [N-acetyl cysteine inhibits human signet ring cell gastric cancer cell line (SJ-89) cell growth by inducing apoptosis and DNA synthesis arrest](https://www.ncbi.nlm.nih.gov/pubmed/?term=human+signet+ring+cell+gastric+cancer+cell+line%2C+NAC)
- [N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals](https://www.ncbi.nlm.nih.gov/pubmed/19427509)
--------
## Deduplicated Source List
- [S-linolenoyl glutathione intake extends life-span and stress resistance via Sir-2.1 upregulation in Caenorhabditis elegans](https://www.ncbi.nlm.nih.gov/pubmed/24835770)
- [Mechanisms underlying the cardioprotective effect of L-cysteine](https://www.ncbi.nlm.nih.gov/pubmed/16132711)
- [Cysteine metabolism and metal toxicity](https://www.ncbi.nlm.nih.gov/pubmed/9727078)
- [A Review on Various Uses of N-Acetyl Cysteine](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241507/)
- [Oxidative Stress and Inflammation in Hepatic Diseases: Therapeutic Possibilities of N-Acetylcysteine](https://www.ncbi.nlm.nih.gov/pubmed/26694382)
- [Glutamate - Neuroscience Bookshelf](https://www.ncbi.nlm.nih.gov/books/NBK10807/)
- [The chemistry and biological activities of N-acetylcysteine - ScienceDirect](https://www.sciencedirect.com/science/article/abs/pii/S030441651300144X)
- [N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044191/)
- [N-Acetylcysteine in depressive symptoms and functionality: a systematic review and meta-analysis](https://www.ncbi.nlm.nih.gov/pubmed/27137430)
- [N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial](https://www.ncbi.nlm.nih.gov/pubmed/26931055)
- [Synaptic and cellular changes induced by the schizophrenia susceptibility gene G72 are rescued by N-acetylcysteine treatment](https://www.ncbi.nlm.nih.gov/pubmed/27163208)
- [N-acetylcysteine, a glutamate modulator, in the treatment of trichotillomania: a double-blind, placebo-controlled study](https://www.ncbi.nlm.nih.gov/pubmed/19581567)
- [N-Acetylcysteine (NAC) in Young Marijuana Users: An Open-Label Pilot Study](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2826714/)
- [Potential Role of N -Acetylcysteine in the Management of Substance Use Disorders | SpringerLink](https://link.springer.com/article/10.1007%2Fs40263-014-0142-x)
- [The promise of N-acetylcysteine in neuropsychiatry](https://www.ncbi.nlm.nih.gov/pubmed/23369637)
- [Efficacy of Ascorbic Acid (Vitamin C) and/N-Acetylcysteine (NAC) Supplementation on Nutritional and Antioxidant Status of Male Chronic Obstructive ..](https://www.ncbi.nlm.nih.gov/pubmed/27117852)
- [The role for N-acetylcysteine in the management of COPD](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706612/)
- [Effect of High/Low Dose N-Acetylcysteine on Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis: COPD: Journal of Chronic Obstructive Pulmonary Disease: Vol 11, No 3](https://www.tandfonline.com/doi/abs/10.3109/15412555.2013.858315)
- [N-acetylcysteine in COPD: why, how, and when?](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744393/)
- [Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clin..](https://www.ncbi.nlm.nih.gov/pubmed/10743980)
- [[N-acetylcystein in the therapy of chronic bronchitis]](https://www.ncbi.nlm.nih.gov/pubmed/12486618)
- [The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review | European Respiratory Society ](https://erj.ersjournals.com/content/16/2/253.short)
- [High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1450222/)
- [N-acetylcysteine protects memory decline induced by streptozotocin in mice](https://www.ncbi.nlm.nih.gov/pubmed/27087133)
- [The role of antioxidant therapy in the treatment of male infertility: an overview](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3739574/)
- [A Preliminary Study: N-acetyl-L-cysteine Improves Semen Quality following Varicocelectomy](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845522/)
- [Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study](https://www.ncbi.nlm.nih.gov/pubmed/19091331)
- [N-Acetyl cysteine and clomiphene citrate for induction of ovulation in polycystic ovary syndrome: a cross-over trial](https://www.ncbi.nlm.nih.gov/pubmed/17364286)
- [The molecular basis for oxidative stress-induced insulin resistance](https://www.ncbi.nlm.nih.gov/pubmed/15998259)
- [L-cysteine supplementation lowers blood glucose, glycated hemoglobin, CRP, MCP-1, and oxidative stress and inhibits NF-kappaB activation in the liv..](https://www.ncbi.nlm.nih.gov/pubmed/19328229)
- [N-acetylcysteine Protects Mice from High Fat Diet-induced Metabolic Disorders](https://www.ncbi.nlm.nih.gov/pubmed/27161488)
- [N-Acetyl Cysteine improves the diabetic cardiac function: possible role of fibrosis inhibition](https://www.ncbi.nlm.nih.gov/pubmed/26242742)
- [N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets](https://www.ncbi.nlm.nih.gov/pubmed/11380598)
- [Green tea polyphenols inhibit human vascular smooth muscle cell proliferation stimulated by native low-density lipoprotein](https://www.ncbi.nlm.nih.gov/pubmed/11755158)
- [Glutathione and immune function](https://www.ncbi.nlm.nih.gov/pubmed/11115795)
- [HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine](https://www.ncbi.nlm.nih.gov/pubmed/1378279)
- [Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine](https://www.ncbi.nlm.nih.gov/pubmed/1418777)
- [Influence of glutathione availability on cell damage induced by human immunodeficiency virus type 1 viral protein R](https://www.ncbi.nlm.nih.gov/pubmed/26597719)
- [N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N..](https://www.ncbi.nlm.nih.gov/pubmed/19732754)
- [N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway](https://www.ncbi.nlm.nih.gov/pubmed/19722195)
- [N-acetyl cysteine inhibits human signet ring cell gastric cancer cell line (SJ-89) cell growth by inducing apoptosis and DNA synthesis arrest](https://www.ncbi.nlm.nih.gov/pubmed/?term=human+signet+ring+cell+gastric+cancer+cell+line%2C+NAC)
- [N-acetyl cysteine protects against ionizing radiation-induced DNA damage but not against cell killing in yeast and mammals](https://www.ncbi.nlm.nih.gov/pubmed/19427509)
- [N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility](https://www.ncbi.nlm.nih.gov/pubmed/18990082)
- [Pharmacokinetics of N-acetylcysteine in man](https://www.ncbi.nlm.nih.gov/pubmed/3803419)
- [Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts](https://www.ncbi.nlm.nih.gov/pubmed/17917164)