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https://github.com/epistasislab/epistasislab.github.io

Identifying the complex genetic architectures of disease
https://github.com/epistasislab/epistasislab.github.io

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Identifying the complex genetic architectures of disease

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README

          

This is the documentation page for the [Epistasis Lab](http://epistasis.org), a research group at at [Cedars-Sinai Medical Center](https://www.cedars-sinai.org/locations/cedars-sinai-main-campus-89.html) in Los Angeles, CA (USA).

In a nutshell, our lab develops computational methods to identify the complex genetic and environmental interactions that lead to human disease.
Our methods address [challenges](http://www.nature.com/nrg/journal/v11/n6/full/nrg2809.html) such as epistasis, heterogeneity, and scalability.

You can browse our projects below for more information.

Methods
===

[EVE](https://github.com/EpistasisLab/EVE): ENSEMBL VEP on EC2

[ellyn](https://epistasislab.github.io/ellyn): A sklearn-compatible linear genetic programming system for symbolic regression and classification.

[ExSTraCS](https://github.com/ryanurbs/ExSTraCS_2.0): Extended Supervised Tracking and Classifying System

[FEAT](https://lacava.github.io/feat): A feature engineering automation tool for regression and classification.

[FEW](https://lacava.github.io/few): A feature engineering wrapper for scikit-learn.

[scikit-mdr](https://github.com/EpistasisLab/scikit-mdr): A sklearn-compatible Python implementation of Multifactor Dimensionality Reduction (MDR) for feature construction.

[scikit-rebate](https://epistasislab.github.io/scikit-rebate/): A scikit-learn-compatible Python implementation of ReBATE, a suite of Relief-based feature selection algorithms for Machine Learning.

[stir](https://github.com/insilico/stir/): ReliefF on steroids

[tpot](https://epistasislab.github.io/tpot/): A Python tool that automatically creates and optimizes machine learning pipelines using genetic programming.

[treeheatr](https://github.com/trang1618/treeheatr): Heatmap-integrated decision tree visualizations

Useful Collections
===

[ClinicalDataSources](https://github.com/EpistasisLab/ClinicalDataSources): Open or Easy Access Clinical Data Sources for Biomedical Research

[Penn ML Benchmarks (PMLB)](https://github.com/EpistasisLab/penn-ml-benchmarks): A large, curated repository of benchmarks for evaluating supervised machine learning algorithms.

[pmlbr](https://github.com/EpistasisLab/pmlbr): an R interface to PMLB