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https://github.com/fabio-cunial/population-sv-simulator

Studies structural variant callers on large simulated populations sequenced with PacBio CCS
https://github.com/fabio-cunial/population-sv-simulator

bioinformatics-pipeline long-reads sequencing-reads structural-variation

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Studies structural variant callers on large simulated populations sequenced with PacBio CCS

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Tools to answer questions about: optimal sequencing parameters in a large PacBio CCS sequencing project; comparative performance of existing SV discovery tools; benefits of joint SV discovery over a large population; limits of SV discovery and motivations for new joint tools.

# Overview of the tools

# Questions

## Which read length and coverage to use for detecting SVs in a large population?

## What are the advantages of joint calling?

## Which SVs are difficult to find?