https://github.com/gunhanb/titepk_sequential
TITE-PK method for sequential phase I trials with multiple schedules
https://github.com/gunhanb/titepk_sequential
bayes pk stan
Last synced: 2 months ago
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TITE-PK method for sequential phase I trials with multiple schedules
- Host: GitHub
- URL: https://github.com/gunhanb/titepk_sequential
- Owner: gunhanb
- License: other
- Created: 2019-07-31T17:02:03.000Z (almost 6 years ago)
- Default Branch: master
- Last Pushed: 2019-07-31T17:09:30.000Z (almost 6 years ago)
- Last Synced: 2025-02-09T02:38:26.415Z (4 months ago)
- Topics: bayes, pk, stan
- Language: Stan
- Homepage:
- Size: 28.3 KB
- Stars: 2
- Watchers: 2
- Forks: 0
- Open Issues: 2
-
Metadata Files:
- Readme: README.md
- License: LICENSE
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README
Implementation of TITE-PK
=========================
This is the accompanying code to paper "Sequential phase I dose-escalation trials with multiple schedules"
by BK Günhan, S Weber, A Seroutou, and T Friede. We consider Everolimus trial to illustrate the use of our
proposed method TITE-PK. See the paper for the details of the methodology.
TITE-PK
=======
TITE-PK (a time-to-event pharmacokinetic model) is a method for designing and analyzing
phase I dose-escalation trials with multiple schedules, eg a daily and weekly dosing.
Here, we consider sequential phase I trials involving multiple treatment schedules.
Computations
============
TITE-PK uses **Stan** via `Rstan`, hence it should be installed.
See [here](https://github.com/stan-dev/rstan/wiki/RStan-Getting-Started)
for how to install it.
`TITEPK_run.R` is the main R-script which produce simulations described in the
main text.
`tite_pk.stan` is the main **Stan** script
which is used in `TITEPK_run.R` to simulate data and implement the TITE-PK model.
Licence
=======
THE SOFTWARE IS PROVIDED "AS IS", WITHOUT WARRANTY OF ANY KIND, EXPRESS OR
IMPLIED, INCLUDING BUT NOT LIMITED TO THE WARRANTIES OF MERCHANTABILITY,
FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT. IN NO EVENT SHALL THE
AUTHORS OR COPYRIGHT HOLDERS BE LIABLE FOR ANY CLAIM, DAMAGES OR OTHER
LIABILITY, WHETHER IN AN ACTION OF CONTRACT, TORT OR OTHERWISE, ARISING FROM,
OUT OF OR IN CONNECTION WITH THE SOFTWARE OR THE USE OR OTHER DEALINGS IN THE
SOFTWARE.
The code was written by [Burak Kürsad
Günhan](http://bkguenhan.rbind.io) and Sebastian Weber. To report any
issues or bugs or to suggest enhancements to the package, please go
[here](https://github.com/gunhanb/TITEPK_sequential/issues).