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https://github.com/lczech/pool-seq-pop-gen-stats


https://github.com/lczech/pool-seq-pop-gen-stats

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README

        

## Pool-Sequencing corrections for population genetic statistics

This repository contains our equations and evaluations of Pool-Sequencing corrections for population genetic statistics. See the [Releases](https://github.com/lczech/pool-seq-pop-gen-stats/releases) for the latest version of the document.

We have implemented the described equations in [grenedalf](https://github.com/lczech/grenedalf).

Versions of this document have been used as supplements in:

> **Monitoring rapid evolution of plant populations at scale with Pool-Sequencing.**
> Lucas Czech, Yunru Peng, Jeffrey P. Spence, Patricia L.M. Lang, Tatiana Bellagio, Julia Hildebrandt, Katrin Fritschi, Rebecca Schwab, Beth A. Rowan, GrENE-net consortium, Detlef Weigel, J.F. Scheepens, François Vasseur, Moises Exposito-Alonso.
> *bioRxiv*, 2022.02.02.477408; [doi:10.1101/2022.02.02.477408](https://doi.org/10.1101/2022.02.02.477408)

and

> **grenedalf: population genetic statistics for the next generation of pool sequencing.**

> Lucas Czech, Jeffrey P. Spence, Moisés Expósito-Alonso.

> Bioinformatics, 2024. doi:[10.1093/bioinformatics/btae508](https://doi.org/10.1093/bioinformatics/btae508)

For the scripts and tests to evaluate the equations and produce the plots shown in this document, see [grenedalf-paper](https://github.com/lczech/grenedalf-paper).