https://github.com/lehai-ml/dhcp_genetics
Analysis of neuroimaging and genetic markers for psychiatric disorders in dHCP
https://github.com/lehai-ml/dhcp_genetics
asd prs python schizophrenia
Last synced: about 1 month ago
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Analysis of neuroimaging and genetic markers for psychiatric disorders in dHCP
- Host: GitHub
- URL: https://github.com/lehai-ml/dhcp_genetics
- Owner: lehai-ml
- Created: 2022-07-14T11:46:50.000Z (almost 4 years ago)
- Default Branch: main
- Last Pushed: 2024-12-16T00:42:20.000Z (over 1 year ago)
- Last Synced: 2024-12-16T01:27:24.780Z (over 1 year ago)
- Topics: asd, prs, python, schizophrenia
- Language: Jupyter Notebook
- Homepage:
- Size: 58.4 MB
- Stars: 1
- Watchers: 2
- Forks: 0
- Open Issues: 0
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Metadata Files:
- Readme: README.md
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README
# Linking neuroimaging markers with genetics of psychiatric disorders in dHCP babies
# Objectives:
Increasing lines of evidence suggest deviations from the normal early developmental trajectory could give rise to a spectrum of psychiatric disorders, ranging from autism spectrum disorders in the early life to schizophrenia during adolescence and young adulthood. On the other hand, the heterogenous manifestation of behavioural symptoms of such diseases gives rise to difficulty in identifiying any real effect. To this end, by forming well-designed hypotheses and examining in individuals with minimal environmental impact such as infants, one may identify informed endophenotypes that provide novel insight into the underlying biological underpinnings of the diseases.
# Research output
**Le, H.**, Dimitrakopoulou, K., Patel, H., Curtis, C., Cordero-Grande, Lucilio, Edwards, D., Hajnal, J., Tournier, J-D., Deprez, M. & Cullen, H. Effect of schizophrenia common variants on infant brain volumes: cross-sectional study in 207 term neonates in developing Human Connectome Project. *Translational Psychiatry*. Accepted/In Press. 2023
**Le, H.**, J., Tournier, J-D., Deprez, M. & Cullen, H. Regional brain lobule variations associated with autisms spectrum disorder polygenic risks scores in term-born infants. Manuscript in Prepration.
# Acknowledgement
This PhD project is supported by the UK Medical Research Coucnil and King's College London member of the MRC Doctoral Training Partnership. Data were provided by the developing Human Connectom Project. The views expressed are those of the authors and not of the funders.