https://github.com/maayanlab/l1000fwd

Large-scale visualization of drug-induced transcriptomic signatures
https://github.com/maayanlab/l1000fwd

data-visualization drug-discovery threejs

Last synced: about 1 month ago
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Large-scale visualization of drug-induced transcriptomic signatures

• Host: GitHub
• URL: https://github.com/maayanlab/l1000fwd
• Owner: MaayanLab
• License: other
• Created: 2018-05-07T16:54:09.000Z (over 6 years ago)
• Default Branch: l1000fwd
• Last Pushed: 2023-07-06T21:05:11.000Z (over 1 year ago)
• Last Synced: 2023-10-20T21:24:14.265Z (about 1 year ago)
• Topics: data-visualization, drug-discovery, threejs
• Language: JavaScript
• Homepage: http://amp.pharm.mssm.edu/L1000FWD/
• Size: 17.6 MB
• Stars: 3
• Watchers: 3
• Forks: 4
• Open Issues: 14
• Metadata Files:
  • Readme: README.md
  • License: LICENSE

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README

        
# L1000FWD: Large-scale Visualization of Drug-induced Transcriptomic Signatures

## About

L1000 fireworks display (L1000FWD) is a web application that provides interactive visualization of over 16,000 drug and small-molecule induced gene expression signatures. L1000FWD enables coloring of signatures by different attributes such as cell type, time point, concentration, as well as drug attributes such as MOA and clinical phase. Signature similarity search is implemented to enable the search for mimicking or opposing signatures given as input of up and down gene sets. Each point on the L1000FWD interactive map is linked to a signature landing page, which provides multifaceted knowledge from various sources about the signature and the drug. Notably such information includes most frequent diagnoses, co-prescribed drugs and age distribution of prescriptions as extracted from the Mount Sinai Health System electronic medical records (EMR). Overall, L1000FWD serves as a platform for identifying functions for novel small molecules using unsupervised clustering, as well as for exploring drug MOA.

## Citation

Wang Z, Lachmann A, Keenan AB, Ma'ayan A (2018) **L1000FWD: fireworks visualization of drug-induced transcriptomic signatures.** _Bioinformatics_ doi: [10.1093/bioinformatics/bty060](https://doi.org/10.1093/bioinformatics/bty060)

## Use

L1000FWD's web-based tools and services are free for academic, non-profit use, but for commercial uses please contact [MSIP](http://www.ip.mountsinai.org/) for a license.

## Disclaimer

L1000FWD IS NOT TO BE USED FOR TREATING OR DIAGNOSING HUMAN SUBJECTS.

L1000FWD or any documents available from this server ARE PROVIDED AS IS WITHOUT ANY WARRANTY OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, INCLUDING, BUT NOT LIMITED TO, ANY IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND FREEDOM FROM INFRINGEMENT, OR THAT L1000FWD or any documents available from this server WILL BE ERROR FREE. The Ma'ayan lab MAKES NO REPRESENTATIONS THAT THE USE OF L1000FWD or any documents available from this server WILL NOT INFRINGE ANY PATENT OR PROPRIETATY RIGHTS OF THIRD PARTIES.

In no event will the Ma'ayan lab or any of its members be liable for any damages, including but not limited to direct, indirect, special or consequential damages, arising out of, resulting from, or in any way connected with the use of L1000FWD or documents available from this server.

##Running instructions

Run package.json to get the node_modules by npm install