https://github.com/matthiaskoenig/aliskiren-model
https://github.com/matthiaskoenig/aliskiren-model
Last synced: 4 months ago
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- Host: GitHub
- URL: https://github.com/matthiaskoenig/aliskiren-model
- Owner: matthiaskoenig
- Created: 2024-09-13T10:32:42.000Z (9 months ago)
- Default Branch: main
- Last Pushed: 2024-09-13T11:19:44.000Z (9 months ago)
- Last Synced: 2025-01-04T20:24:30.265Z (5 months ago)
- Size: 107 KB
- Stars: 0
- Watchers: 1
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
Awesome Lists containing this project
README
[](https://doi.org/10.5281/zenodo.13758627)
# aliskiren model
This repository provides the aliskiren physiologically based pharmacokinetics (PBPK) model.
The model is distributed as [SBML](http://sbml.org) available from [`aliskiren_body_flat.xml`](./models/aliskiren_body_flat.xml) with
corresponding SBML4humans model report at [https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_body_flat.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_body_flat.xml) and equations from [`aliskiren_body_flat.md`](./models/aliskiren_body_flat.md).
### Comp submodels
The liver submodel is available from [`aliskiren_liver.xml`](./models/aliskiren_liver.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_liver.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_liver.xml) and equations from [`aliskiren_liver.md`](./models/aliskiren_liver.md).
The kidney submodel is available from [`aliskiren_kidney.xml`](./models/aliskiren_kidney.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_kidney.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_kidney.xml) and equations from [`aliskiren_kidney.md`](./models/aliskiren_kidney.md).
The intestine submodel is available from [`aliskiren_intestine.xml`](./models/aliskiren_intestine.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_intestine.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_intestine.xml) and equations from [`aliskiren_intestine.md`](./models/aliskiren_intestine.md).
The whole-body submodel is available from [`aliskiren_body.xml`](./models/aliskiren_body.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_body.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/aliskiren-model/main/models/aliskiren_body.xml) and equations from [`aliskiren_body.md`](./models/aliskiren_body.md).
## How to cite
[](https://doi.org/10.5281/zenodo.13758627)
> Kulanoglu, Y. A., & König, M. (2024).
> *Physiologically based pharmacokinetic (PBPK) model of aliskiren.*
> Zenodo. [https://doi.org/10.5281/zenodo.13758627](https://doi.org/10.5281/zenodo.13758627)
## License
* Source Code: [LGPLv3](http://opensource.org/licenses/LGPL-3.0)
* Documentation: [CC BY-SA 4.0](http://creativecommons.org/licenses/by-sa/4.0/)
* Models: [CC BY-SA 4.0](http://creativecommons.org/licenses/by-sa/4.0/)
The aliskiren-model source is released under both the GPL and LGPL licenses version 2 or
later. You may choose which license you choose to use the software under.
This program is free software: you can redistribute it and/or modify it under
the terms of the GNU General Public License or the GNU Lesser General Public
License as published by the Free Software Foundation, either version 2 of the
License, or (at your option) any later version.
This program is distributed in the hope that it will be useful, but WITHOUT ANY
WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A
PARTICULAR PURPOSE. See the GNU General Public License for more details.
Funding
=======
Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).
© 2024 Yusuf Ali Kulanoglu & Matthias König, [Systems Medicine of the Liver](https://livermetabolism.com)