https://github.com/matthiaskoenig/glimepiride-model
Physiologically based pharmacokinetic (PBPK) model of glimepiride
https://github.com/matthiaskoenig/glimepiride-model
Last synced: 3 months ago
JSON representation
Physiologically based pharmacokinetic (PBPK) model of glimepiride
- Host: GitHub
- URL: https://github.com/matthiaskoenig/glimepiride-model
- Owner: matthiaskoenig
- Created: 2025-01-10T14:54:17.000Z (5 months ago)
- Default Branch: main
- Last Pushed: 2025-01-10T15:09:45.000Z (5 months ago)
- Last Synced: 2025-01-20T21:59:08.623Z (5 months ago)
- Size: 95.7 KB
- Stars: 0
- Watchers: 1
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
Awesome Lists containing this project
README
[](https://doi.org/10.5281/zenodo.14628700)
# glimepiride model
This repository provides the glimepiride physiologically based pharmacokinetics (PBPK) model.
The model is distributed as [SBML](http://sbml.org) available from [`glimepiride_body_flat.xml`](./models/glimepiride_body_flat.xml) with
corresponding SBML4humans model report at [https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_body_flat.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_body_flat.xml) and equations from [`glimepiride_body_flat.md`](./models/glimepiride_body_flat.md).
### Comp submodels
The liver submodel is available from [`glimepiride_liver.xml`](./models/glimepiride_liver.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_liver.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_liver.xml) and equations from [`glimepiride_liver.md`](./models/glimepiride_liver.md).
The kidney submodel is available from [`glimepiride_kidney.xml`](./models/glimepiride_kidney.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_kidney.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_kidney.xml) and equations from [`glimepiride_kidney.md`](./models/glimepiride_kidney.md).
The intestine submodel is available from [`glimepiride_intestine.xml`](./models/glimepiride_intestine.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_intestine.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_intestine.xml) and equations from [`glimepiride_intestine.md`](./models/glimepiride_intestine.md).
The whole-body submodel is available from [`glimepiride_body.xml`](./models/glimepiride_body.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_body.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/glimepiride-model/main/models/glimepiride_body.xml) and equations from [`glimepiride_body.md`](./models/glimepiride_body.md).
## How to cite
[](https://doi.org/10.5281/zenodo.14628700)
> Elias, M., & König, M. (2025).
> *Physiologically based pharmacokinetic (PBPK) model of glimepiride.*
> Zenodo. [https://doi.org/10.5281/zenodo.14628700](https://doi.org/10.5281/zenodo.14628700)
## License
* Source Code: [MIT](https://opensource.org/license/MIT)
* Documentation: [CC BY-SA 4.0](https://creativecommons.org/licenses/by-sa/4.0/)
* Models: [CC BY-SA 4.0](https://creativecommons.org/licenses/by-sa/4.0/)
Funding
=======
Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).
© 2024-2025 Michelle Elias & Matthias König, [Systems Medicine of the Liver](https://livermetabolism.com)