https://github.com/matthiaskoenig/icg-model
Indocyanine green physiological based pharmacokinetics model (PBPK)
https://github.com/matthiaskoenig/icg-model
Last synced: 4 months ago
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Indocyanine green physiological based pharmacokinetics model (PBPK)
- Host: GitHub
- URL: https://github.com/matthiaskoenig/icg-model
- Owner: matthiaskoenig
- Created: 2021-10-06T08:03:15.000Z (over 3 years ago)
- Default Branch: main
- Last Pushed: 2021-10-06T11:54:56.000Z (over 3 years ago)
- Last Synced: 2025-01-04T20:24:39.909Z (5 months ago)
- Homepage:
- Size: 727 KB
- Stars: 0
- Watchers: 4
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
Awesome Lists containing this project
README
[](https://doi.org/10.5281/zenodo.5552397)
# ICG model
This repository provides the indocyanine green physiological based pharmacokinetics model (PBPK) described in
> Prediction of survival after partial hepatectomy using a physiologically based pharmacokinetic model of indocyanine green liver function tests
*Adrian Köller, Jan Grzegorzewski, Hans-Michael Tautenhahn, Matthias König*
bioRxiv 2021.06.15.448411; doi: [https://doi.org/10.1101/2021.06.15.448411](https://doi.org/10.1101/2021.06.15.448411)
The model is distributed as [SBML](http://sbml.org) available from [`icg_body_flat.xml`](./models/icg_body_flat.xml) with
corresponding SBML4humans model report at [https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/icg-model/main/models/icg_body_flat.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/icg-model/main/models/icg_body_flat.xml)
### Comp submodels
The liver submodel is available from [`icg_liver.xml`](./models/icg_liver.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/icg-model/main/models/icg_liver.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/icg-model/main/models/icg_liver.xml)
The whole-body submodel is available from [`icg_body.xml`](./models/icg_body.xml) with corresponding SBML4humans report at
[https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/icg-model/main/models/icg_body.xml](https://sbml4humans.de/model_url?url=https://raw.githubusercontent.com/matthiaskoenig/icg-model/main/models/icg_body.xml)
## How to cite
Prediction of survival after partial hepatectomy using a physiologically based pharmacokinetic model of indocyanine green liver function tests
*Adrian Köller, Jan Grzegorzewski, Hans-Michael Tautenhahn, Matthias König*
bioRxiv 2021.06.15.448411; doi: [https://doi.org/10.1101/2021.06.15.448411](https://doi.org/10.1101/2021.06.15.448411)
## License
* Source Code: [LGPLv3](http://opensource.org/licenses/LGPL-3.0)
* Documentation: [CC BY-SA 4.0](http://creativecommons.org/licenses/by-sa/4.0/)
* Models: [CC BY-SA 4.0](http://creativecommons.org/licenses/by-sa/4.0/)
The icg-model source is released under both the GPL and LGPL licenses version 2 or
later. You may choose which license you choose to use the software under.
This program is free software: you can redistribute it and/or modify it under
the terms of the GNU General Public License or the GNU Lesser General Public
License as published by the Free Software Foundation, either version 2 of the
License, or (at your option) any later version.
This program is distributed in the hope that it will be useful, but WITHOUT ANY
WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A
PARTICULAR PURPOSE. See the GNU General Public License for more details.
Funding
=======
Adrian Köller and Matthias König are supported by the Federal Ministry of Education and Research (BMBF, Germany)
within the research network Systems Medicine of the Liver (**LiSyM**, grant number 031L0054). Matthias König
is supported by the German Research Foundation (DFG) within the Research Unit Programme FOR 5151
[QuaLiPerF](https://qualiperf.de) (Quantifying Liver Perfusion-Function Relationship in Complex Resecti)
A Systems Medicine Approach)" by grant number 436883643.
© 2020-2021 [Matthias König](https://livermetabolism.com)