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https://github.com/mrc-ide/rtss-ce
Cost-effectiveness of RTS,S vs. scale-up of existing interventions.
https://github.com/mrc-ide/rtss-ce
Last synced: 10 days ago
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Cost-effectiveness of RTS,S vs. scale-up of existing interventions.
- Host: GitHub
- URL: https://github.com/mrc-ide/rtss-ce
- Owner: mrc-ide
- Created: 2022-01-11T16:26:40.000Z (almost 3 years ago)
- Default Branch: main
- Last Pushed: 2023-04-04T14:31:32.000Z (almost 2 years ago)
- Last Synced: 2024-11-06T02:32:17.358Z (about 2 months ago)
- Language: R
- Size: 6.55 MB
- Stars: 1
- Watchers: 2
- Forks: 2
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
Awesome Lists containing this project
README
# RTSS-CE :earth_africa: :syringe: :heavy_dollar_sign:
Strategic resource allocation to maximize the impact of malaria response.
## Objectives
:one: To evaluate the relative cost-effectiveness and related uncertainty of introducing the RTS,S malaria vaccine compared to scale-up of existing malaria interventions.
- As part of a threshold analysis: what is the minimum cost per fully vaccinated child to make the vaccine cost-effective compared to scaling existing malaria interventions for a given country setting?
:two: What is the optimal sequencing of malaria interventions in order to maximize impact in resource constrained settings?
- What are the key determinants of the cost-effectiveness rankings?
- How do the uncertainties/assumptions on costs and effectiveness of malaria interventions play a role in this ranking?
- Is this ranking consistent across regions or countries with similar epidemiological profiles?
- What is the equity implication of alternative scale up scenarios?
## Directory
```
.
├── 01_data # Data files
├── 02_code # R code file
| ├── HPC_draws # HPC runs for parameter draws
| | ├── A_parameter_draws.R # List parameters for each draw
| | ├── B_PfPR_EIR_match.R # Match PfPR to EIR
| | ├── C_HPC_runs.R # HPC runs
| | ├── function_draws.R # Functions for HPC
| | ├── Processing # Data processing
| | | ├── cost_effectiveness.R # Process CE
| | | ├── HPC_processing.R # Helper-function HPC output
| | | ├── add_costs.R # Helper-function add costs
| | | ├── deaths_dalys.R # Helper-function calc deaths & DALYs
| | | ├── netz_dist.R # Helper-function calc nets distributed
| | | ├── outcome_averted.R # Helper-function calc DALYs and cases averted
| | ├── Processing_casestudy # Data processing - case study
| | | ├── cost_effectiveness.R # Process CE
| | | ├── HPC_processing.R # Helper-function HPC output
| ├── Figures # Re-create paper figures
| ├── MISC_calibrate_test.R # Test calibration output function
| ├── MISC_ITN_usage_distribution.R # Determine model input ITN coverage values to reach population usages
| ├── MISC_SMCdosetest.R # Determine which SMC profiles should be used
| ├── MISC_warmup_time_test.R # Determine the warmup time needed
├── 03_output # PDF figures and .rds files
├── GF_RTSS_CE.Rproj # R.Studio project file
└── README.md # Project overview
```
## R package versions
malariasimulation: 1.3.0
malariaequilibrium: 1.0.1
individual: 0.1.9
cali: https://github.com/mrc-ide/cali/tree/adbc370450716a2231347094c68cf7b31419896c
netz: https://github.com/mrc-ide/netz/tree/0ce236c34f36cb4d533260f88563dc4e09d3ba65
treasure: https://github.com/mrc-ide/treasure/tree/36a5498f4a3bea07e4a6cb4390e955dac359409a