https://github.com/mrp01/insilicocancercell

https://github.com/mrp01/insilicocancercell

Last synced: about 21 hours ago
JSON representation

• Host: GitHub
• URL: https://github.com/mrp01/insilicocancercell
• Owner: MrP01
• Created: 2024-03-04T13:15:58.000Z (9 months ago)
• Default Branch: master
• Last Pushed: 2024-04-15T14:18:40.000Z (7 months ago)
• Last Synced: 2024-04-16T03:20:35.868Z (7 months ago)
• Language: MATLAB
• Size: 8.4 MB
• Stars: 0
• Watchers: 1
• Forks: 0
• Open Issues: 0
• Metadata Files:
  • Readme: README.md

Awesome Lists containing this project

README

        
# Electrophysiological Cancer Cell Model

![PyPI - Version](https://img.shields.io/pypi/v/in-silico-cancer-cell)

Attempt to model an A549 cancer cell's ion channels using an HMM (Hidden Markov Model) and simulation of voltage + current development accross the membrane of the cell.

This software comes in three flavours:

- to run the `main.rs` simulation, do `cargo run`,

- to compile the Python module, do `maturin develop --features pyo3`,

- to precompile for the Astro dashboard, do `yarn run wasm-pack build frontend`.

## A visual to capture your interest:

![Ion Channels](https://journals.plos.org/ploscompbiol/article/figure/image?size=large&download=&id=10.1371/journal.pcbi.1009091.g002)

(Image source: [here](https://doi.org/10.1371/journal.pcbi.1009091.g002)).

This computational model is based on [Langthaler et al., 2021](https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009091): **A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma**.

## The Simulation Dashboard

![Screenshot of the User Interface](./figures/full-length-screenshot.png)