https://github.com/nifets/torusevol

This is a Bayesian model for sequence and structure alignment of multiple proteins in a star phylogeny. The structural divergence across time is modelled by letting the dihedral angles of the backbones evolve according to a diffusion over the flat square torus.
https://github.com/nifets/torusevol

bayesian-inference gibbs-sampling monte-carlo-sampling protein-structure sequence-alignment structure-alignment

Last synced: 2 days ago
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This is a Bayesian model for sequence and structure alignment of multiple proteins in a star phylogeny. The structural divergence across time is modelled by letting the dihedral angles of the backbones evolve according to a diffusion over the flat square torus.

• Host: GitHub
• URL: https://github.com/nifets/torusevol
• Owner: nifets
• Created: 2023-03-24T14:28:40.000Z (almost 3 years ago)
• Default Branch: main
• Last Pushed: 2023-06-20T12:00:57.000Z (over 2 years ago)
• Last Synced: 2025-04-03T04:14:32.038Z (11 months ago)
• Topics: bayesian-inference, gibbs-sampling, monte-carlo-sampling, protein-structure, sequence-alignment, structure-alignment
• Language: Julia
• Homepage:
• Size: 19.7 MB
• Stars: 0
• Watchers: 1
• Forks: 0
• Open Issues: 0
• Metadata Files:
  • Readme: README.md

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README

          
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[![Screenshot1](jumpingdiff.png "Screenshot1")]()

[![Screenshot2](evol_traj_globins.png "Screenshot2")]()

(WIP) Sequence and structure evolution model for proteins

- statistical alignment

- torsional angle diffusion