https://github.com/nignatiadis/ihw

Independent Hypothesis Weighting
https://github.com/nignatiadis/ihw

ihw pvalue-adjustment

Last synced: 26 days ago
JSON representation

Independent Hypothesis Weighting

• Host: GitHub
• URL: https://github.com/nignatiadis/ihw
• Owner: nignatiadis
• Created: 2015-08-06T14:11:21.000Z (over 9 years ago)
• Default Branch: master
• Last Pushed: 2023-09-25T00:46:25.000Z (over 1 year ago)
• Last Synced: 2024-12-09T08:03:45.019Z (27 days ago)
• Topics: ihw, pvalue-adjustment
• Language: R
• Homepage: https://bioconductor.org/packages/devel/bioc/html/IHW.html
• Size: 1.08 MB
• Stars: 15
• Watchers: 3
• Forks: 5
• Open Issues: 4
• Metadata Files:
  • Readme: README.md

Awesome Lists containing this project

README

        

# Independent Hypothesis Weighting

Independent hypothesis weighting (IHW) is a multiple testing procedure that increases power compared to the method of Benjamini and Hochberg by assigning

data-driven weights to each hypothesis. The input to IHW is a two-column

table of p-values and covariates. The covariate can be any continuous-valued

or categorical variable that is thought to be informative on the statistical

properties of each hypothesis test, while it is independent of the p-value

under the null hypothesis. IHW is described in the following paper:

> N. Ignatiadis, B. Klaus, J.B. Zaugg, W. Huber. *Data-driven hypothesis weighting increases detection power in genome-scale multiple testing.* Nature methods. 2016 Jul;13(7):577-80.

Also see the following paper for the theoretical underpinning of the method:

> N. Ignatiadis and W. Huber. *Covariate-powered cross weighted multiple testing.*  [[arXiv]](https://arxiv.org/abs/1701.05179)

# Software availability

The package is available on  [Bioconductor](https://www.bioconductor.org/packages/devel/bioc/html/IHW.html), and may be installed as follows:

```R

if (!requireNamespace("BiocManager", quietly=TRUE))

    install.packages("BiocManager")

BiocManager::install("IHW")

```

The package can be installed as follows with `devtools` from the Github repository:

```R

devtools::install_github("nignatiadis/IHW")

```