https://github.com/novartis/moabox

A repository of compound-target annotations in support of Systematic Chemogenetic Library Assembly
https://github.com/novartis/moabox

Last synced: 4 months ago
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A repository of compound-target annotations in support of Systematic Chemogenetic Library Assembly

• Host: GitHub
• URL: https://github.com/novartis/moabox
• Owner: Novartis
• Created: 2020-04-03T15:18:57.000Z (about 6 years ago)
• Default Branch: master
• Last Pushed: 2020-06-03T14:13:30.000Z (about 6 years ago)
• Last Synced: 2025-12-08T12:05:08.151Z (6 months ago)
• Homepage:
• Size: 10.3 MB
• Stars: 17
• Watchers: 5
• Forks: 3
• Open Issues: 1
• Metadata Files:
  • Readme: README.md

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README

          
## Readme

A repository of compound-target annotations in support of Systematic Chemogenetic Library Assembly

Supplementary materials to accompany [bioRxiv](https://www.biorxiv.org/) preprint manuscript [Systematic Chemogenetic Library Assembly](https://www.biorxiv.org/content/10.1101/2020.03.30.017244v1)

### Copyright 

The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC-ND 4.0 International license](http://creativecommons.org/licenses/by-nc-nd/4.0/).

## Abstract

The assembly of chemogenetic libraries composed of chemical probes provides tremendous value to biomedical research, but requires substantial effort to ensure diversity as well as quality of the contents. We are assembling a chemogenetic library by data mining and crowdsourcing institutional expertise. We are sharing our methodology, lessons learned, and disclosing our current collection of 4186 compounds with their primary annotated gene targets. 

## Authors

Stephen M. Canham1*, Yuan Wang1, Allen Cornett1, Douglas S. Auld1*, Daniel K. Baeschlin2, Maude Patoor2, Philip R. Skaanderup2, Ayako Honda1, Luis Llamas1, Greg Wendel1, Felipa A. Mapa1, Peter Aspesi Jr. 1, Nancy Labbe-Giguere1, Gabriel G. Gamber1, Daniel S. Palacios1, Ansgar Schuffenhauer2, Zhan Deng1, Florian Nigsch2, Mathias Frederiksen2, Simon M. Bushell1, Deborah Rothman1, Rishi K. Jain1, Horst Hemmerle1, Karin Briner1, Jeffery A. Porter1, John A. Tallarico1, Jeremy L. Jenkins1* 

1 *Novartis Institute for BioMedical Research, 181 Massachusetts Ave Cambridge, MA 02139*

2 *Novartis Institute for Biomedical Research, Novartis Pharma AG, Forum 1 Novartis Campus, 4056 Basel, Switzerland* 

*e-mail: steve.canham@novartis.com; douglas.auld@novartis.com; jeremy.jenkins@novartis.com