https://github.com/sing-group/pandrugs-backend
A Java backend for the PanDrugs application
https://github.com/sing-group/pandrugs-backend
bioinformatics cancer database drugs personal-medicine
Last synced: 3 months ago
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A Java backend for the PanDrugs application
- Host: GitHub
- URL: https://github.com/sing-group/pandrugs-backend
- Owner: sing-group
- License: gpl-3.0
- Created: 2015-06-02T09:13:12.000Z (over 10 years ago)
- Default Branch: master
- Last Pushed: 2022-12-10T03:57:36.000Z (almost 3 years ago)
- Last Synced: 2023-02-27T07:56:26.249Z (over 2 years ago)
- Topics: bioinformatics, cancer, database, drugs, personal-medicine
- Language: Java
- Homepage: http://www.pandrugs.org
- Size: 1.15 MB
- Stars: 3
- Watchers: 4
- Forks: 1
- Open Issues: 8
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Metadata Files:
- Readme: README.md
- License: LICENSE
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README
# pandrugs-backend
A Java backend for the PanDrugs.
## Project description
**PanDrugs** provides a platform **to guide the selection of therapies from the results of genome-wide studies in cancer
disease**.
Using 4 alternative inputs (e.g. standard VCF files, RNK files, gene list and drug query), **PanDrugs identify
actionable molecular alterations and prioritize drugs by calculating gene-drug scores** which takes into account:
i) genomic feature evidence by mutation impact score; ii) target pathway context; iii) drug approval status (FDA,
clinical trial or experimental small molecule inhibitors) and iv) manually-curated pharmacological information retrieved
from the literature.
**PanDrugs scores combines biological and clinical relevance of the genes and their susceptibility to be targeted**
reflecting the strength or evidence level of the gene-drug association in order to assist the clinical decision making.
PanDrugs current version integrates data from 18 primary sources and supports ~50,000 drug-target associations obtained
from ~6,000 genes and ~11,000 unique compounds.