https://github.com/zakwht/ace2

An investigation into the effects of ACE2 mutations with respect to its interactions with the SARS-CoV-2 spike protein
https://github.com/zakwht/ace2

bioinformatics python sars-cov-2 tex undergrad

Last synced: 17 days ago
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An investigation into the effects of ACE2 mutations with respect to its interactions with the SARS-CoV-2 spike protein

• Host: GitHub
• URL: https://github.com/zakwht/ace2
• Owner: zakwht
• License: gpl-3.0
• Created: 2021-12-07T23:58:33.000Z (over 4 years ago)
• Default Branch: main
• Last Pushed: 2021-12-21T00:47:24.000Z (over 4 years ago)
• Last Synced: 2025-03-12T06:28:37.704Z (over 1 year ago)
• Topics: bioinformatics, python, sars-cov-2, tex, undergrad
• Language: TeX
• Homepage:
• Size: 637 KB
• Stars: 0
• Watchers: 2
• Forks: 0
• Open Issues: 0
• Metadata Files:
  • Readme: README.md
  • License: LICENSE.md

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README

          
# Identifying Mutations in ACE2 That Influence Susceptibility to SARS-CoV-2

[![License](https://img.shields.io/github/license/zakwht/ace2)](/LICENSE.md)

[![Report](https://img.shields.io/badge/report-2021-orange.svg)](/report/report.pdf)

### Abstract

SARS-CoV-2 is an contagious virus established to affect not only humans, but other mammal species. Studies over the last two years have revealed certain species are distinctly immune to the virus, a reality this report aims to understand. By analyzing the differences between sequences of the virus’ target protein, ACE2, in hosts with varying susceptibility to the virus, this study investigates mutations that may impact a host’s vulnerability. 

The analysis identifies eight mutations that may influence susceptibility (D31, A41, A66, F83, N113, H353, S426, V679), five of which are referenced in other studies.

### Acknowledgments

* __Designed under the instruction of__ [H. Jabbari and A. Ziesel](https://onlineacademiccommunity.uvic.ca/cobra/team/)

* __Planned with help from__ Samantha Mitchell