https://github.com/alwinw/epoc-aki

📈 Evaluation of the Predictive value of short-term Oliguria and minor Creatinine increases for Acute Kidney Injury in ICU
https://github.com/alwinw/epoc-aki

acute-kidney-failure aki bookdown classification creatinine kidney logistic-regression oliguria r rmd statistical-analysis time-series

Last synced: 5 months ago
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📈 Evaluation of the Predictive value of short-term Oliguria and minor Creatinine increases for Acute Kidney Injury in ICU

• Host: GitHub
• URL: https://github.com/alwinw/epoc-aki
• Owner: alwinw
• License: gpl-3.0
• Created: 2019-12-29T09:38:26.000Z (over 6 years ago)
• Default Branch: master
• Last Pushed: 2022-07-31T10:08:42.000Z (almost 4 years ago)
• Last Synced: 2025-09-05T02:18:08.141Z (9 months ago)
• Topics: acute-kidney-failure, aki, bookdown, classification, creatinine, kidney, logistic-regression, oliguria, r, rmd, statistical-analysis, time-series
• Language: R
• Homepage:
• Size: 84.3 MB
• Stars: 9
• Watchers: 0
• Forks: 1
• Open Issues: 1
• Metadata Files:
  • Readme: README.md
  • License: LICENSE
  • Citation: CITATION.cff

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README

          
# The EPOC-AKI Study 

Evaluation of the Predictive value of short-term Oliguria and minor Creatinine increases for Acute Kidney Injury (AKI) in ICU

- Austin Health ResearchFest 2020: [Virtual Poster Presentation](https://doi.org/10.6084/m9.figshare.13055699.v1)

- Journal of Critical Care article: [Small, short-term, point-of-care creatinine changes as predictors of acute kidney injury in critically ill patients](https://doi.org/10.1016/j.jcrc.2022.154097)

## Data Overview

### Definitions

![Data Overview](/doc/images/overview.png)

Changes in Creatinine Episodes:

- Creatinine change during episode (µmol/L): Δcr

- Duration of creatinine change episode (hrs): Δtcr_ch = Ti - (Ti - δt)

- Time between end of cr change epis and AKI (hrs or NA): Δtaki = TAKI - Ti

Oliguria Episodes:

- Time Oliguria identified: Tolig = T0

- Time Oliguria episode started: Tolig_4 = T0 - 4

- Time between olig epis and AKI (hrs or NA): Δtaki - TAKI - T0

### Exploration

![Data Exploration](/doc/images/heatmap_AKI_ICU.png)

Example: Significant difference in creatinine changes 8 < Δtcr_ch < 12 between 'No AKI' and 'tAKI in 4-8 hrs'

## Running

1. Clone the repository and open the R project file `epoc-aki.Rproj` with RStudio

    ```bash

    git clone git@github.com:alwinw/epoc-api.git

    ```

2. Preview the relevant `bookdown` file

   - Option 1: Open the file directly in RStudio

      1. Open up the bookdown index, e.g. `doc/full/index.Rmd`

      2. In RStudio run `Addins` > `Preview Book`, or from the console run

        ```R

        bookdown::serve_book()

        ```

   - Option 2: Run `serve_book` from the console

        ```R

        bookdown::serve_book(dir = "doc/full/")

        ```

3. Preview the bookdown site at `http://localhost:4321/` or `http://127.0.0.1:4321/`

## Contributors

Alwin Wang and Lisa Toh

## Acknowledgements

## Activity

![GitHub commit activity](https://img.shields.io/github/commit-activity/m/alwinw/epoc-aki?style=flat-square)

![GitHub last commit](https://img.shields.io/github/last-commit/alwinw/epoc-aki?style=flat-square)

![Visits](https://badges.pufler.dev/visits/alwinw/epoc-aki?style=flat-square&label=visits)

![GitHub repo size in bytes](https://img.shields.io/github/repo-size/alwinw/epoc-aki?style=flat-square)

![Total Lines](https://img.shields.io/tokei/lines/github/alwinw/epoc-aki?style=flat-square)

## License

[![GitHub](https://img.shields.io/github/license/alwinw/epoc-aki?style=flat-square)](LICENSE)

- [GPL-3.0 License](https://opensource.org/licenses/GPL-3.0)

- Copyright 2020 © [Alwin Wang](https://github.com/alwinw) and [Lisa Toh](https://github.com/lymt)