https://github.com/bradleyedelman/combo-window
The COMBO Window is a chronic cranial implant for mice, designed for long-term, multimodal neural recordings.
https://github.com/bradleyedelman/combo-window
3d-printing behavior-analysis cranial-implant-design electrophysiology functional-ultrasound neuroimaging time-series-analysis two-photon-imaging
Last synced: about 2 months ago
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The COMBO Window is a chronic cranial implant for mice, designed for long-term, multimodal neural recordings.
- Host: GitHub
- URL: https://github.com/bradleyedelman/combo-window
- Owner: BradleyEdelman
- Created: 2024-09-17T13:26:05.000Z (almost 2 years ago)
- Default Branch: main
- Last Pushed: 2025-02-12T08:22:30.000Z (over 1 year ago)
- Last Synced: 2025-02-12T09:40:09.014Z (over 1 year ago)
- Topics: 3d-printing, behavior-analysis, cranial-implant-design, electrophysiology, functional-ultrasound, neuroimaging, time-series-analysis, two-photon-imaging
- Language: MATLAB
- Homepage:
- Size: 1.52 MB
- Stars: 0
- Watchers: 1
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
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README
# COMBO Window
This repository contains **3D printer (and laser cutter) files**, as well as **analysis and plotting code** associated with the validation of the **COMBO Window**—a chronic cranial implant for multiscale circuit interrogation in mice.
## 📄 Related Publication
### **The COMBO Window: A Chronic Cranial Implant for Multiscale Circuit Interrogation in Mice**
**B. J. Edelman & D. Siegenthaler et al., PLOS Biology, 2024**
- Introduces **a novel cranial implant** that enables **long-term, multimodal neural recordings** in head-fixed moving mice.
- **Key contributions:**
- **Supports multiple imaging modalities** (two-photonimaging, functional ultrasound imaging, electrophysiology).
- Enables **stable, chronic recordings months after implantation** while maintaining high-quality optical access.
- **Designed for easy fabrication and open-source sharing** using 3D printing and laser cutting.
📄 [Read the full paper](https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002664)
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## 📂 Open-Source Data
The full dataset used for validation is available on **Edmond (MPG Open Science)**:
[View Data on Edmond](https://edmond.mpg.de/dataset.xhtml?persistentId=doi:10.17617/3.5KYYHK)
---
## 🛠️ 3D Printer Files & Plotting Code
The **3D models, laser cutter files, and plotting code** are hosted on **Zenodo**:
[Download files from Zenodo](https://zenodo.org/records/11092491)
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## Summary
The **COMBO Window** is an **open-source cranial implant** designed for long-term **multimodal neural recordings in mice**. This repository provides:
- **3D printer & laser cutter files** for fabrication.
- **Analysis & plotting scripts** for validation data.
- **Open-access datasets & code** for reproducibility and further development.