https://github.com/certara/simcyp-r-scripts
Simcyp R example scripts
https://github.com/certara/simcyp-r-scripts
pbpk pbpk-modeling
Last synced: 19 days ago
JSON representation
Simcyp R example scripts
- Host: GitHub
- URL: https://github.com/certara/simcyp-r-scripts
- Owner: certara
- Created: 2023-11-07T13:53:16.000Z (over 2 years ago)
- Default Branch: main
- Last Pushed: 2026-02-12T11:04:51.000Z (5 months ago)
- Last Synced: 2026-07-06T05:33:29.432Z (19 days ago)
- Topics: pbpk, pbpk-modeling
- Language: R
- Homepage:
- Size: 87 MB
- Stars: 1
- Watchers: 1
- Forks: 0
- Open Issues: 0
-
Metadata Files:
- Readme: README.md
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README
# Simcyp R Example Scripts
## Description
A package to support R script interactions with the Simcyp simulator (V23-V25). Provides functions to initialise Simcyp, load and modify workspaces and interrogate results.
## System Requirements
* Windows 10
* Simcyp Simulator license
* R >= 4.5.1
## Installation
The Simcyp R Package requires additional package dependencies, which can first be installed from CRAN using the following command:
```r
install.packages(c("Rcpp", "xml2", "RcppThread", "R.utils", "RSQLite", "DBI", "rlang", "tibble", "fs", "PKNCA", "dplyr", "stringr", "ggplot2", "pracma", "rstudioapi"))
```
The Simcyp R package is distributed from Simcyp support via a download link and can be requested from simcyp.support@certara.com.
First, download the package archive file from the Simcyp download portal, then navigate to RStudio \> Tools \> Install Packages. In the "Install from:" dropdown selection, change to "Package archive file" and select the Simcyp R package `.zip` file in your file explorer.
The current Released Version of the Simcyp R package is `Simcyp_25.0.44.zip`.
## Examples
Navigate to one of the example folders within the repository to view usage details.
## Support
Please email simcyp.support@certara.com for any queries.
## Learning material:
If you are a Simcyp license members, E-Learning videos can be viewed via your members area.
Other learning videos can be found on YouTube:
* [Simcyp R package overview](https://youtu.be/9KuWlyrPMko?si=nuXK41YlvI4IWx28)
* [Simcyp R package overview v21](https://youtu.be/htlC2EvDWTk?si=NEKdw5i6u3oCI43S)
* [Summary statistics and ribbon plots](https://youtu.be/qn5YVLGPis4?si=7N85NKH8S229tITR)
* [Forest plots](https://youtu.be/bi6M6IpCYdc?si=gzMcdbEolDqc7hpl)
## Publications:
* [SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp® simulator](https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.929200/full)
* [Using the Simcyp R Package for PBPK Simulation Workflows With the Simcyp Simulator](https://pubmed.ncbi.nlm.nih.gov/40179011/)