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https://github.com/genentech/mrgsolve_replace_nmsim


https://github.com/genentech/mrgsolve_replace_nmsim

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# mrgsolve_replace_NMsim
Purpose: use mrgsolve to replace `$SIM` and `vpc` with NONMEM/psn

The main motivation is to avoid using NONMEM for any simulation tasks (and associated dataset generation & CSV handling), so that the only NONMEM run you would do is $EST.
You still need to develop `mrgsolve` model file, but from my experience that effort will pays off quite immediately.

## Quick look

See https://genentech.github.io/mrgsolve_replace_NMsim/01_mrgsolve_replace_NMsim.html for output from the RMarkdown template

## How to use

You can download this repository from the green `Clone or download` button on top right.
Once cloned or unarchived the ZIP file, you can double-click "mrgsolve_replace_NMsim.Rproj" to open this repository in RStudio.

The main RMarkdown template file is `script/01_mrgsolve_replace_NMsim.Rmd`, which should be directly executable once you install all the necessary R packages from CRAN.

## Author

This tool was initiated by Kenta Yoshida (yoshida.kenta@gene.com) within Genentech Clinical Pharmacology Department.

## License

The source code is distributed under a MIT license. Full description can be found in [LICENSE.txt](LICENSE.txt)