https://github.com/jackhump/fus_intron_retention
Scripts written for the FUS NLS mutation comparison with FUS KO project
https://github.com/jackhump/fus_intron_retention
Last synced: 5 months ago
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Scripts written for the FUS NLS mutation comparison with FUS KO project
- Host: GitHub
- URL: https://github.com/jackhump/fus_intron_retention
- Owner: jackhump
- Created: 2019-03-04T21:39:07.000Z (over 7 years ago)
- Default Branch: master
- Last Pushed: 2020-06-08T16:44:31.000Z (about 6 years ago)
- Last Synced: 2023-10-20T20:31:58.349Z (over 2 years ago)
- Language: R
- Size: 60.5 KB
- Stars: 1
- Watchers: 3
- Forks: 0
- Open Issues: 0
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Metadata Files:
- Readme: README.md
Awesome Lists containing this project
README
# *FUS* ALS-causative mutations impact FUS autoregulation and the processing of RNA-binding proteins through intron retention
**Jack Humphrey**
[paper now published at Nucleic Acids Research](https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa410/5849905)
All code written in R and presented as Rmarkdown documents for readability.
Accompanying scripts:
#### 01_differential_expression/
- 01_DESeq_joint_modelling.Rmd
- 02_iCLIP_gene_expression.Rmd
#### 02_differential_splicing/
- 01_SGSeq_joint_modelling.Rmd
- 02_SGSeq_variant_function.Rmd
- 03_SGSeq_plotting.Rmd
- 04_compare_expression_splicing.Rmd
#### 03_autoregulation/
- 01_FUS_intron_retention_plotting.Rmd
- 02_Autoregulation_validation.Rmd
#### 04_comparing_other_data/
- 01_TDP_cross_regulation.Rmd
- 02_Luisier_VCP_cross_regulation.Rmd
#### 05_heterozygotes/
- Comparing_Hets.Rmd
#### 06_CLIPdb_FUS_introns/
- retained_intron_clip.R