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https://github.com/mstorath/dcebe

Estimation of bolus arrival times for DCE-MRI signals
https://github.com/mstorath/dcebe

bolus-arrival-time dce-mri splines

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Estimation of bolus arrival times for DCE-MRI signals

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# Bolus arrival time estimation for DCE-MRI signals (DCEBE)

## Description
This Matlab code estimates the bolus arrival time (BAT) of DCE-MRI signals.
It is particularly intended to work with signals that do not have a fast upslope
as it is often the case for data of small animals.
The proposed method employs a spline-based approximation model.
Parameter estimation is done by generalized cross validation.

A detailed documentation of the method is given in
the paper A. Bendinger, C. Debus, C. Glowa, C. Karger, J. Peter, M. Storath,
[Bolus arrival time estimation in dynamic contrast-enhanced MRI of small animals based on spline models,](https://doi.org/10.1088/1361-6560/aafce7)
Physics in Medicine & Biology, Volume 64, Number 4, 2019.
[preprint link](https://arxiv.org/pdf/1811.10672.pdf). [![View DCEBE on File Exchange](https://www.mathworks.com/matlabcentral/images/matlab-file-exchange.svg)](https://de.mathworks.com/matlabcentral/fileexchange/69526-dcebe)

## Quickstart
- Run "DCEC_install.m" or add subfolders manually to Matlab path
- Run a demo script from the demos folder, e.g. "DCEBE_demo.m"

## How to cite
The method is described in the paper

- A. Bendinger, C. Debus, C. Glowa, C. Karger, J. Peter, M. Storath,
[Bolus arrival time estimation in dynamic contrast-enhanced MRI of small animals based on spline models](https://doi.org/10.1088/1361-6560/aafce7)
Physics in Medicine & Biology, Volume 64, Number 4, 2019

## Acknowledgement
Thanks to T. Driscoll for sharing his code for [computing finite difference weights.](https://de.mathworks.com/matlabcentral/fileexchange/13878-finite-difference-weights)