https://github.com/phydev/spiccato

Software developed to study the influence of the extracellular matrix in cell migration.
https://github.com/phydev/spiccato

cell-biology mathematical-modelling metastasis modeling phase-field

Last synced: about 2 months ago
JSON representation

Software developed to study the influence of the extracellular matrix in cell migration.

• Host: GitHub
• URL: https://github.com/phydev/spiccato
• Owner: phydev
• License: gpl-3.0
• Created: 2019-09-09T00:30:22.000Z (over 5 years ago)
• Default Branch: master
• Last Pushed: 2023-08-28T12:57:50.000Z (over 1 year ago)
• Last Synced: 2023-10-20T22:22:27.769Z (over 1 year ago)
• Topics: cell-biology, mathematical-modelling, metastasis, modeling, phase-field
• Language: Fortran
• Homepage: https://phydev.github.io/SPiCCAto
• Size: 4.35 MB
• Stars: 3
• Watchers: 1
• Forks: 0
• Open Issues: 1
• Metadata Files:
  • Readme: README.md
  • License: LICENSE

Awesome Lists containing this project

README

        
[![Build Status](https://travis-ci.com/phydev/SPiCCAto.svg?branch=master)](https://travis-ci.com/phydev/SPiCCAto)

[![codecov](https://codecov.io/gh/phydev/SPiCCAto/branch/master/graph/badge.svg?token=RpWeuCwJzu)](https://codecov.io/gh/phydev/SPiCCAto)

[![License: GPL v3](https://img.shields.io/badge/License-GPLv3-blue.svg)](https://www.gnu.org/licenses/gpl-3.0)

[![DOI](https://zenodo.org/badge/DOI/10.5281/zenodo.3534284.svg)](https://doi.org/10.5281/zenodo.3534284)

## Software PaCkage for Cell reseArch

This project is hosted by the [CFisUC](http://cfisuc.fis.uc.pt/) at the [University of Coimbra](www.uc.pt) 

and consists in a phase-field model for multicellular systems.

This software was developed to study how the mechanical constraints imposed by the extracellular matrix (ECM) affect cell migration. We explored a phase-field model that describes the fibres and the cell as order parameters that interact by repulsion and adhesion. 

### Publications

M. Moreira-Soares, S. Pinto-Cunha, J. R. Bordin, R. D. M. Travasso. *["Adhesion modulates cell morphology and migration within dense fibrous networks"](https://www.biorxiv.org/content/10.1101/838995v1)*.  https://doi.org/10.1101/838995

![alt tag](https://raw.githubusercontent.com/phydev/SPiCCAto/master/docs/static_figs/cell_moving.gif)