https://github.com/stolarczyk/BALCONY

R package: BALCONY (Better ALignment CONsensus analYsis)
https://github.com/stolarczyk/BALCONY

alignment conservation evolutionary-biology protein protein-tunnels

Last synced: about 2 months ago
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R package: BALCONY (Better ALignment CONsensus analYsis)

• Host: GitHub
• URL: https://github.com/stolarczyk/BALCONY
• Owner: stolarczyk
• Created: 2018-02-13T15:05:56.000Z (over 6 years ago)
• Default Branch: master
• Last Pushed: 2022-06-01T09:06:57.000Z (over 2 years ago)
• Last Synced: 2024-06-11T08:48:40.308Z (4 months ago)
• Topics: alignment, conservation, evolutionary-biology, protein, protein-tunnels
• Language: R
• Homepage:
• Size: 2.94 MB
• Stars: 3
• Watchers: 3
• Forks: 4
• Open Issues: 5
• Metadata Files:
  • Readme: README.md

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README

        
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# BALCONY

This repository holds the BALCONY R package, which can be downloaded at its [CRAN](https://CRAN.R-project.org/package=BALCONY) website.

**BALCONY** (Better ALignment CONsensus analYsis) is an R package that facilitates the evolutionary analysis and the

identification of conservation check the variablity of selected amino acids in protein

structure.

One of the unique functionalities of the BALCONY package concerns the

analysis of individual amino acids in primary protein structure and their neighbours

in tertiary structure. Residues defining active site cavities, co-factor binding sites,

selectivity filters, channels or tunnels are examples of applications for this package.

BALCONY is flexible and versatile enough to combine and analyse evolutionary and

structural data in a simple and transparent manner.

Conservation analysis can provide insights into rational protein design. Amino

acids favoured by evolution are attractive hot spots for mutations prediction.

Conversely, the most variable residues may also be great candidates for enzyme

property enhancements since theoretically these are not fundamental for protein

stability.

## Package installation

``` install.packages("BALCONY") ```

## Publication

See the [publication](https://doi.org/10.1186/s12859-018-2294-z) introducing the BALCONY package. 

Alicja Płuciennik, Michał Stolarczyk, Maria Bzówka, Agata Raczyńska, Tomasz Magdziarz, and Artur Góra. “BALCONY: An R Package for MSA and Functional Compartments of Protein Variability Analysis.” BMC Bioinformatics 19, no. 1 (August 14, 2018): 300. https://doi.org/10.1186/s12859-018-2294-z.