SBML
SBML (the Systems Biology Markup Language) is an XML-based format for communicating and storing representations of biological processes. Its aim is to be a lingua franca for representing models in biology. SBML is suitable for models commonly found in research on a number of topics, including cell signaling pathways, metabolic pathways, biochemical reactions, gene regulation, and many others.
- GitHub: https://github.com/topics/sbml
- Wikipedia: https://en.wikipedia.org/wiki/SBML
- Repo: https://github.com/sbmlteam
- Released: March 2001
- Related Topics: xml, systems-biology, computational-biology,
- Last updated: 2025-09-23 00:28:52 UTC
- JSON Representation
https://github.com/sorgerlab/indra
INDRA (Integrated Network and Dynamical Reasoning Assembler) is an automated model assembly system interfacing with NLP systems and databases to collect knowledge, and through a process of assembly, produce causal graphs and dynamical models.
bioinformatics biology computational-biology indra modeling nlp pysb sbml systems-biology
Last synced: 15 May 2025
https://github.com/amici-dev/amici
High-performance sensitivity analysis for large ordinary differential equation models
adjoint-sensitivities cvode cvodes differentialequations forward-sensitivities hacktoberfest idas kinetic-modeling mechanistic-models modeling ode parameter-estimation petab pysb python sbml sensitivities sensitivity-analysis simulation systemsbiology
Last synced: 21 Oct 2025
https://github.com/AMICI-dev/AMICI
Advanced Multilanguage Interface to CVODES and IDAS
adjoint-sensitivities cvode cvodes differentialequations forward-sensitivities hacktoberfest idas kinetic-modeling mechanistic-models modeling ode parameter-estimation petab pysb python sbml sensitivities sensitivity-analysis simulation systemsbiology
Last synced: 04 May 2025
https://github.com/sciml/sbmltoolkit.jl
SBML differential equation and chemical reaction model (Gillespie simulations) for Julia's SciML ModelingToolkit
chemical-reaction-networks differential-equations gillespie-algorithm julia ode quantitative-systems-pharmacology sbml sciml systems-biology
Last synced: 06 May 2025
https://github.com/darrenjw/smfsb
Documentation, models and code relating to the 3rd edition of the textbook Stochastic Modelling for Systems Biology
gillespie-algorithm inference mcmc sbml systems-biology
Last synced: 21 Jun 2025
https://github.com/lcsb-biocore/sbml.jl
Julia interface to the Systems Biology Markup Language (SBML) library
cobra libsbml modeling sbml systems-biology
Last synced: 02 Apr 2025
https://github.com/LoLab-MSM/pyvipr
Jupyter widget for the dynamic and static visualizations of systems biology models written in PySB, BNGL, and SBML
bionetgen cytoscapejs jupyter-widget jupyterlab-extension network-visualization networkx pysb sbgn sbml systems-biology tellurium visualization
Last synced: 28 Oct 2025
https://github.com/lolab-msm/pyvipr
Jupyter widget for the dynamic and static visualizations of systems biology models written in PySB, BNGL, and SBML
bionetgen cytoscapejs jupyter-widget jupyterlab-extension network-visualization networkx pysb sbgn sbml systems-biology tellurium visualization
Last synced: 10 Apr 2025
https://github.com/sbmlteam/sbml-test-suite
The SBML Test Suite is a conformance testing system. It allows developers and users to test the degree and correctness of the SBML support provided in a software package.
ode sbml sbml-models simulation stochastic systems-biology test-automation testing testing-framework testing-tools
Last synced: 25 Dec 2025
https://github.com/matthiaskoenig/cy3sbml
cy3sbml: SBML for Cytoscape 3
cytoscape graphs sbml systems-biology visualization
Last synced: 13 May 2025
https://github.com/biosimulators/Biosimulators
Registry of containerized biosimulation tools that support a standard command-line interface
combine computational-biology docker kinetic-model kisao mathematical-model omex reproducibility reuse sbml sbo sed-ml simulation systems-biology
Last synced: 14 Oct 2025
https://github.com/sbmlteam/moccasin
MOCCASIN translates basic ODE-based MATLAB models of biological processes into SBML format.
conversion differential-equations matlab ode ode-model python sbml systems-biology
Last synced: 17 Dec 2025
https://github.com/matthiaskoenig/dfba
Encoding Dynamic Flux Balance Analysis in SBML
Last synced: 23 Feb 2025
https://github.com/EBI-BioModels/SBO
The Systems Biology Ontology (SBO) is a set of controlled, relational vocabularies of terms commonly used in Systems Biology, and in particular in computational modeling.
biosimulators computational-biology mathematical-modeling numerical-simulation obofoundry ontology sbml systems-biology
Last synced: 11 Mar 2025
https://github.com/matthiaskoenig/fbc_curation
FROG analysis in python for the reproducibility of FBC models
Last synced: 19 Oct 2025
https://github.com/lobolab/mergem
mergem is a python package and command-line tool for merging, comparing, and translating genome-scale metabolic models
genome-scale-models sbml systems-biology
Last synced: 22 Jul 2025
https://github.com/spatialsimulator/XitoSBML
XitoSBML - the spatial SBML plugin for ImageJ
fiji imagej sbml spatial-sbml-plugin systems-biology
Last synced: 07 May 2025
https://github.com/sbmlteam/sbml-spatial-models
Repository of models to test exchange of sbml-spatial models.
Last synced: 25 Dec 2025
https://github.com/matthiaskoenig/sbmlsim
sbmlsim: SBML simulation made easy
Last synced: 23 Feb 2025
https://github.com/sbmlteam/deviser
Design Explorer and Viewer for Iterative SBML Enhancement of Representations
automation code-generation code-generator libsbml python sbml systems-biology xml
Last synced: 25 Dec 2025
https://github.com/paulflang/sbml2julia
A tool to for optimizing parameters of ordinary differential equation (ODE) models. SBML2Julia translates a model from SBML/PEtab format into Julia for Mathematical Programming (JuMP), performs the optimization task and returns the results.
julia modelling ode optimization ordinary-differential-equations sbml sbml-model systems-biology
Last synced: 15 Apr 2025
https://github.com/brsynth/neo4jsbml
Bridge the gap between SBML data and Neo4j
Last synced: 16 Jan 2026
https://github.com/rivm-syso/euromix-to-sbml
Antimony/SBML re-implementation of the EuroMix Generic PBK model.
Last synced: 17 Jan 2026
https://github.com/paulflang/sbmlinterface.jl
Interface between the Systems Biology Markup Language and Julia
differential-equations julia modelling ode ordinary-differential-equations sbml sbml-model systems-biology
Last synced: 15 Apr 2025
https://github.com/sbmlteam/sbmlpkgspec
A LaTeX document class providing a standard format for SBML Level 3 package specification documents.
documentation documents latex sbml
Last synced: 25 Dec 2025
https://github.com/gibbslab/minval
An R package to identify orphan metabolites and evaluate the mass and charge balance of stoichiometric reactions. The package also includes functions to characterize and write models in TSV and SBML formats, extract all reactants, products, metabolite names and compartments from a metabolic reconstruction.
bioinformatics charge-balance cran mass-balance metabolic-models metabolism minval sbml stoichiometric-reactions
Last synced: 22 Oct 2025
https://github.com/dilawar/drawsbml
Draw Signalling Pathway (SBML format)
drawing graphviz sbml signalling
Last synced: 23 Feb 2025
https://github.com/matthiaskoenig/cy2sbml
cy2sbml: SBML for Cytoscape 2
cytoscape cytoscape-plugin sbml
Last synced: 23 Feb 2025
https://github.com/sbmlteam/mathml-tests
Tests for infix-to-mathML and mathML-to-infix for both libsbml and jsbml.
Last synced: 25 Dec 2025
https://github.com/alexoarga/findcritical
A desktop app, web app and CLI to operate and find vulnerabilities in SBML metabolic networks.
Last synced: 17 Mar 2025
https://github.com/biosimulators/biosimulators_copasi
COPASI biochemical network simulation program via BioSimulators-compliant command-line interface and Docker container
biochemical-networks biosimulators combine-archive computational-biology copasi docker dynamical-modeling omex-metadata python sbml sed-ml simulation systems-biology
Last synced: 14 Jan 2026
https://github.com/x-jiang-bioe/sb2l
Translates the biological models written in SBML into LaTeX code to be compiled and read by human eye
Last synced: 22 Mar 2025
https://github.com/sbmlteam/new-sbml-software-guide
A summer project to develop a fresh new SBML Software Guide
Last synced: 25 Dec 2025
https://github.com/sbmlteam/sbml-level-3-paper-overleaf
Copy of Overleaf project for the SBML Level 3 paper submitted to MSB
Last synced: 25 Dec 2025
https://github.com/cthoyt/biomodels-metadata-analysis
Generate a summary of metadata annotations in the BioModels database
biomodels fair-data modeling reproducibility-crisis sbml systems-biology
Last synced: 15 Jun 2025
https://github.com/cobrexa/sbmlfbcmodels.jl
AbstractFBCModel interface for SBML.jl
Last synced: 02 Mar 2025
https://github.com/fbergmann/pyodide-copasi
Vue3 Project using Pyodide / basico and python-copasi emscripten
copasi primevue sbml sbml-simulation vue3
Last synced: 18 Jan 2026
https://github.com/alaa2133/cobra
[SIGGRAPH 2025] Official code of the paper "Cobra: Efficient Line Art COlorization with BRoAder References"
cli cobra-generator cobra-toolbox code-audit go golang-library modeling posix-compliant-flags python sbml security-scanner strain-engineering subcommands transcriptomics
Last synced: 23 Apr 2025
https://github.com/matthiaskoenig/glimepiride-app
Glimepiride Web Application
digital-twin digital-twin-application sbml sbml-model
Last synced: 03 Sep 2025
https://github.com/sbmlteam/sbml-level-3-paper-response-letter
Response to reviewers for SBML Level 3 paper submitted to MSB
Last synced: 25 Dec 2025
https://github.com/matthiaskoenig/iri-model
Hepatocyte model of ischemia reperfusion injury (IRI)
Last synced: 23 Feb 2025